The relationship between anxiety and quality of life among people with epilepsy: The mediating effect of depression

IF 2.3 3区医学 Q2 BEHAVIORAL SCIENCES

Epilepsy & Behavior Pub Date : 2025-02-04 DOI:10.1016/j.yebeh.2025.110274

Liuxiang Wei , Yuan Lv , DingYue Peng , Mei Liang , Dongdong Jiang , Xiaoqin Gan , Jiaofeng Deng , Xianghua He , Xiaolin Ni , Caiyou Hu

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引用次数: 0

Abstract

Objectives

The interactions of anxiety, depression, and the quality of life (QOL) in people with epilepsy (PWE) are unclear. This research aimed to explore how anxiety and depression interact to influence QOL.

Methods

The QOL, anxiety and depression of 1162 PWE were investigated via questionnaires and 849 of PWE were finally used in the statistical analyses. Mediation analysis was conducted to analyzed the mediating effect of depression in the relationship between anxiety and QOL.

Results

849 PWE with a mean age of 46.62 ± 14.01 (range, 18–85) years were included finally, and 61.2 % were male. Mediation analysis revealed that depression indirectly mediated the relationship between anxiety and QOL (B = -0.445, bootstrap 95 % CI = −0.497 to −0.394). On the total score and the six out of seven domains of QOLIE-31 (seizure worry, overall QOL, emotional well-being, energy/fatigue, cognitive function, and social function), the indirect effect of depression (range, 51.0 %-68.9 %) are exceeded the direct effect of anxiety. Concerning the “medication effect”, the indirect effect (36.0 %) of depression is smaller.

Conclusions

The effect of anxiety on QOL is mainly explained by the partial mediation of depression. Specifically, anxiety primarily affects QOL through the effect of depression on the total QOL score and the other six domains. However, the direct effect of anxiety was stronger for the medication effect domain.

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来源期刊

Epilepsy & Behavior 医学-行为科学

CiteScore

5.40

自引率

15.40%

发文量

385

审稿时长

43 days

期刊介绍： Epilepsy & Behavior is the fastest-growing international journal uniquely devoted to the rapid dissemination of the most current information available on the behavioral aspects of seizures and epilepsy. Epilepsy & Behavior presents original peer-reviewed articles based on laboratory and clinical research. Topics are drawn from a variety of fields, including clinical neurology, neurosurgery, neuropsychiatry, neuropsychology, neurophysiology, neuropharmacology, and neuroimaging. From September 2012 Epilepsy & Behavior stopped accepting Case Reports for publication in the journal. From this date authors who submit to Epilepsy & Behavior will be offered a transfer or asked to resubmit their Case Reports to its new sister journal, Epilepsy & Behavior Case Reports.