Extrusion bioprinting: meeting the promise of human tissue biofabrication?

IF 5 Q1 ENGINEERING, BIOMEDICAL
Ian Holland
{"title":"Extrusion bioprinting: meeting the promise of human tissue biofabrication?","authors":"Ian Holland","doi":"10.1088/2516-1091/adb254","DOIUrl":null,"url":null,"abstract":"<p><p>Extrusion is the most popular bioprinting platform. Predictions of human tissue and whole-organ printing have been made for the technology. However, after decades of development, extruded constructs lack the essential microscale resolution and heterogeneity observed in most human tissues. Extrusion bioprinting has had little clinical impact with the majority of research directed away from the tissues most needed by patients. The distance between promise and reality is a result of technology hype and inherent design flaws that limit the shape, scale and survival of extruded features. By more widely adopting resolution innovations and softening its ambitions the biofabrication field could define a future for extrusion bioprinting that more closely aligns with its capabilities.</p>","PeriodicalId":74582,"journal":{"name":"Progress in biomedical engineering (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":5.0000,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894458/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in biomedical engineering (Bristol, England)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1088/2516-1091/adb254","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0

Abstract

Extrusion is the most popular bioprinting platform. Predictions of human tissue and whole-organ printing have been made for the technology. However, after decades of development, extruded constructs lack the essential microscale resolution and heterogeneity observed in most human tissues. Extrusion bioprinting has had little clinical impact with the majority of research directed away from the tissues most needed by patients. The distance between promise and reality is a result of technology hype and inherent design flaws that limit the shape, scale and survival of extruded features. By more widely adopting resolution innovations and softening its ambitions the biofabrication field could define a future for extrusion bioprinting that more closely aligns with its capabilities.

挤压生物打印:实现人体组织生物制造的承诺?
挤出是最流行的生物打印平台。人类组织和整个器官的打印技术已经被预测。然而,经过几十年的发展,挤出结构缺乏在大多数人体组织中观察到的必要的微尺度分辨率和异质性。挤压生物打印几乎没有临床影响,大多数研究直接远离患者最需要的组织。承诺和现实之间的距离是技术炒作和固有设计缺陷的结果,这些缺陷限制了挤压功能的形状、规模和生存。通过更广泛地采用分辨率创新和软化其野心,生物制造领域可以定义挤出生物打印的未来,使其更紧密地与其能力保持一致。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
9.40
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信