Association between Estimated Small Dense Low-Density Lipoprotein-cholesterol (sdLDL-C) and Atherosclerotic Cardiovascular Disease Risk.

Shutang Zhang, Jinjie Du, Peng Wang, Min Lei, Canye Zhong, Yang Ou, Zhen Sun
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Abstract

Background: A new formula for estimating small, dense, low-density lipoprotein cholesterol (sdLDL-C) based on the results of the standard lipid panel is proposed.

Objectives: To assess the association between estimated sdLDL-C (EsdLDL-C) and atherosclerotic cardiovascular disease (ASCVD) risk.

Methods: A total of 12,192 participants from the Korea National Health and Nutrition Examination Survey (KNHANES) database between 2010 and 2020 were included in this cross-sectional study. EsdLDL-C was calculated as EsdLDL-C= LDL-C - [1.43 × LDL-C - (0.14 × (ln (TG) × LDL-C)) - 8.99]. Logistic regression analyses were utilized to assess the association between EsdLDL-C and ASCVD risk. Subgroup analyses were performed based on age, body mass index (BMI), hypertension, and diabetes. An odds ratio (OR) with a 95% confidence interval (CI) was used for evaluation. P<0.05 was considered statistically significant.

Results: Among 12,192 participants, 1,239 (10.16%) had ASCVD. The mean sdLDL-C of participants was estimated to be 42.43±14.75 mg/dL using the formula. Elevated EsdLDL-C levels (OR=1.33; 95%CI, 1.06-1.66) were associated with an increased risk of ASCVD. Subgroup analyses found that there may be an interaction between EsdLDL-C (Pinteraction= 0.001) or non-HDL-C (Pinteraction= 0.015) and hypertension on ASCVD risk.

Conclusions: Elevated estimated sdLDL-C levels were associated with the risk of ASCVD, and estimated sdLDL-C might be an alternative to sdLDL-C measurement for ASCVD risk assessment.

估计的小密度低密度脂蛋白-胆固醇(sdLDL-C)与动脉粥样硬化性心血管疾病风险之间的关系
背景:提出了一种基于标准脂质面板结果估算小、密、低密度脂蛋白胆固醇(sdLDL-C)的新公式。目的:评估估计的sdLDL-C (EsdLDL-C)与动脉粥样硬化性心血管疾病(ASCVD)风险之间的关系。方法:从2010年至2020年的韩国国家健康和营养检查调查(KNHANES)数据库中,共有12192名参与者被纳入这项横断面研究。计算EsdLDL-C为EsdLDL-C= LDL-C - [1.43 × LDL-C - (0.14 × (ln (TG) × LDL-C)) - 8.99]。采用Logistic回归分析评估EsdLDL-C与ASCVD风险之间的关系。根据年龄、体重指数(BMI)、高血压和糖尿病进行亚组分析。采用比值比(OR)和95%置信区间(CI)进行评价。结果:在12192名参与者中,1239名(10.16%)患有ASCVD。使用该公式估计参与者的平均sdLDL-C为42.43±14.75 mg/dL。EsdLDL-C水平升高(OR=1.33;95%CI, 1.06-1.66)与ASCVD风险增加相关。亚组分析发现,EsdLDL-C (p - interaction= 0.001)或非hdl - c (p - interaction= 0.015)与高血压之间可能存在ASCVD风险的相互作用。结论:估计的sdLDL-C水平升高与ASCVD风险相关,估计的sdLDL-C可能是ASCVD风险评估中sdLDL-C测量的替代方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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