Gender differences in the association between childhood trauma, clinical symptoms, and cognitive function in Chinese patients with chronic schizophrenia.

IF 3.6 2区医学 Q1 PSYCHIATRY

Social Psychiatry and Psychiatric Epidemiology Pub Date : 2025-02-05 DOI:10.1007/s00127-025-02826-2

ZhaoXuan Shang, ChunQing Fang, GuoShuai Luo, XiaoE Lang, Xiangyang Zhang

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Abstract

Purpose: This study investigates the gender-specific associations between childhood trauma, clinical symptoms, and cognitive function in Chinese patients with chronic schizophrenia.

Methods: A total of 601 patients with chronic schizophrenia were evaluated using the Childhood Trauma Questionnaire-Short Form (CTQ-SF), the Positive and Negative Syndrome Scale (PANSS), and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Correlation and regression analyses were performed to explore the relationships between childhood trauma and clinical symptoms and cognitive function, considering gender differences.

Results: Childhood trauma prevalence showed no gender differences. In male patients, physical neglect predicted PANSS Positive symptoms (β = 0.123), and physical abuse was linked to lower Visuospatial Construction scores (β = -0.103). In female patients, emotional neglect predicted PANSS Positive (β = 0.225) and Excitement factors (β = 0.197), and emotional abuse predicted Depressive symptoms (β = 0.186). Sexual abuse was associated with lower language scores (β = -0.204), and physical neglect with deficits in Immediate (β = -0.261) and Delayed Memory (β = -0.157).

Conclusion: The findings highlight distinct gender-specific patterns in the impact of childhood trauma on clinical symptoms among patients with chronic schizophrenia. This suggests the necessity for gender-specific therapeutic interventions to address these differences effectively.

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中国慢性精神分裂症患者童年创伤、临床症状和认知功能之间的性别差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Social Psychiatry and Psychiatric Epidemiology 医学-精神病学

CiteScore

8.50

自引率

2.30%

发文量

184

审稿时长

3-6 weeks

期刊介绍： Social Psychiatry and Psychiatric Epidemiology is intended to provide a medium for the prompt publication of scientific contributions concerned with all aspects of the epidemiology of psychiatric disorders - social, biological and genetic. In addition, the journal has a particular focus on the effects of social conditions upon behaviour and the relationship between psychiatric disorders and the social environment. Contributions may be of a clinical nature provided they relate to social issues, or they may deal with specialised investigations in the fields of social psychology, sociology, anthropology, epidemiology, health service research, health economies or public mental health. We will publish papers on cross-cultural and trans-cultural themes. We do not publish case studies or small case series. While we will publish studies of reliability and validity of new instruments of interest to our readership, we will not publish articles reporting on the performance of established instruments in translation. Both original work and review articles may be submitted.