Translational Research on Polygenic Risk Scores in Common Neurodegenerative Diseases - A Scoping Review Protocol.

Q3 Medicine
Mojca Čižek Sajko, Jana Suklan, Džanan Osmanović, Borut Peterlin
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引用次数: 0

Abstract

Objective: The purpose of this protocol is to clearly describe the process for the scoping review we plan to conduct on the topic of polygenic risk scores (PRS) in common neurodegenerative diseases. We will present the review's objective, the strategy for evidence search, the data extraction and analysis procedure, and how the results will be presented.

Methods: The inclusion criteria for the planned scoping review will focus on evidence sources that involve PRS applied to neurogenerative diseases such as Multiple sclerosis, Parkinson's disease, Alzheimer's disease, and Amyotrophic lateral sclerosis in any phase of translational research, from early development to clinical implementation. This includes its use in risk prediction, early diagnosis, prognosis, and treatment decision-making. The research questions were created based on the population, context, and concept framework. We will consider both peer-reviewed papers and grey literature published in English or German for inclusion. Two independent reviewers will search for information.

Concluison: The findings from the scoping review will be presented descriptively and summarized according to the research questions to illustrate the current status of translational research on PRS in common neurodegenerative diseases.

常见神经退行性疾病多基因风险评分的转化研究-一项范围审查方案。
目的:本方案的目的是明确描述我们计划对常见神经退行性疾病的多基因风险评分(PRS)主题进行范围审查的过程。我们将介绍综述的目标,证据检索策略,数据提取和分析程序,以及如何呈现结果。方法:计划范围审查的纳入标准将侧重于从早期开发到临床实施的任何转化研究阶段,涉及PRS应用于神经变性疾病(如多发性硬化症、帕金森病、阿尔茨海默病和肌萎缩侧索硬化症)的证据来源。这包括在风险预测、早期诊断、预后和治疗决策方面的应用。研究问题是根据人口、背景和概念框架创建的。我们将考虑同行评议的论文和以英语或德语发表的灰色文献。两名独立评审员将搜索信息。结论:本文将根据研究问题对范围综述的结果进行描述和总结,以说明PRS在常见神经退行性疾病中的转化研究现状。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Acta medica academica
Acta medica academica Medicine-Medicine (all)
CiteScore
1.90
自引率
0.00%
发文量
21
审稿时长
15 weeks
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