Clinical evaluation of platelet-to-albumin ratio as a predictor of surgical site infection in pediatric patients with ulcerative colitis.

IF 1.6 4区 医学 Q2 SURGERY
Surgery Today Pub Date : 2025-08-01 Epub Date: 2025-02-04 DOI:10.1007/s00595-025-02997-0
Koki Higashi, Yuhki Koike, Yuki Sato, Ma Ruiya, Shinji Yamashita, Yuka Nagano, Tadanobu Shimura, Takahito Kitajima, Kohei Matsushita, Yoshiki Okita, Yoshinaga Okugawa, Yuji Toiyama
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引用次数: 0

Abstract

Purpose: This study explored the predictive factors for surgical site infection (SSI) in a pediatric ulcerative colitis (UC) population.

Methods: Data from 35 patients with UC who underwent surgery before 15 years at Mie University Hospital between January 2000 and December 2022 were retrospectively reviewed. Potential preoperative and intraoperative predictors of SSI, including various demographic and clinical variables, were analyzed using the Mann-Whitney U test and logistic regression analysis. The optimal cutoff value for the variables was determined by examining the receiver operating characteristic curve.

Results: Of the 35 patients, 8 (22.9%) experienced SSI. The platelet-to-albumin ratio (PAR) is a more accurate predictor of SSI occurrence than the serum albumin level, platelet count, or C-reactive protein level. The sensitivity and specificity of PAR were 75.0% and 77.8%, respectively, with an area under the curve (AUC) of 0.782 (p = 0.018). A multivariable analysis revealed that preoperative PAR was the only significant independent predictor (cutoff value: 115,000, p = 0.047) when the optimal cutoff value was applied rather than the median value.

Conclusions: This study demonstrated the value of the preoperative PAR in the management of pediatric patients with UC. Assessing the patient's PAR before surgery allows proactive treatment to reduce the risk of SSI.

血小板-白蛋白比作为小儿溃疡性结肠炎患者手术部位感染预测因子的临床评价
目的:本研究探讨小儿溃疡性结肠炎(UC)人群手术部位感染(SSI)的预测因素。方法:回顾性分析2000年1月至2022年12月在Mie大学医院接受15年前手术的35例UC患者的资料。术前和术中SSI的潜在预测因素,包括各种人口统计学和临床变量,采用Mann-Whitney U检验和logistic回归分析进行分析。通过检查受试者工作特性曲线,确定各变量的最佳截止值。结果:35例患者中,8例(22.9%)发生SSI。血小板-白蛋白比(PAR)比血清白蛋白水平、血小板计数或c反应蛋白水平更准确地预测SSI的发生。PAR的敏感性为75.0%,特异性为77.8%,曲线下面积(AUC)为0.782 (p = 0.018)。多变量分析显示,当采用最佳截断值而不是中位数时,术前PAR是唯一显著的独立预测因子(截断值:115,000,p = 0.047)。结论:本研究证明了术前PAR在小儿UC患者治疗中的价值。在手术前评估患者的PAR可以进行积极的治疗以降低SSI的风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Surgery Today
Surgery Today 医学-外科
CiteScore
4.90
自引率
4.00%
发文量
208
审稿时长
1 months
期刊介绍: Surgery Today is the official journal of the Japan Surgical Society. The main purpose of the journal is to provide a place for the publication of high-quality papers documenting recent advances and new developments in all fields of surgery, both clinical and experimental. The journal welcomes original papers, review articles, and short communications, as well as short technical reports("How to do it"). The "How to do it" section will includes short articles on methods or techniques recommended for practical surgery. Papers submitted to the journal are reviewed by an international editorial board. Field of interest: All fields of surgery.
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