Accelerated Resolution Therapy for Cancer Distress and Post-Traumatic Stress Symptoms: Results of a Pilot Study.

IF 3.3 2区 医学 Q2 ONCOLOGY
Cindy Tofthagen, Kristine A Donovan, Jay Mandrekar, Harleah G Buck
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引用次数: 0

Abstract

Background: An estimated one-third of cancer survivors suffer from post-traumatic stress (PTS) symptoms. PTS is associated with high levels of cancer distress, anxiety, and depression. Few evidence-based treatments are available for PTS. Accelerated Resolution Therapy (ART) is a form of trauma-focused psychological therapy that has been found to be both safe and effective at alleviating post-traumatic stress symptoms, psychological distress, anxiety and depressive symptoms in non-cancer populations.

Methods: The purpose of this single arm, pilot study was to examine the preliminary efficacy of ART for alleviating post-traumatic stress symptoms, cancer distress, depressive symptoms and anxiety among cancer survivors, as well as to evaluate baseline characteristics of persons most likely to respond to ART. Participants were provided with five ART sessions and outcome variables were assessed at enrollment, immediately following ART, and 30 days post ART. Paired t-tests were used to examine differences between scores at each time point. Associations between the PCL-5 score from baseline to post 30-day visit were assessed and other variables were examined using univariate linear regression.

Results: In a sample of 20 cancer survivors, statistically significant decreases in PTS symptoms (p < 0.0001), cancer distress (p < 0.0001), anxiety (p = 0.0002), and depression (p < 0.0001) from pre to post intervention were present. These improvements remained 30 days post-intervention. Higher baseline PCL-5 scores, as well as higher scores on two subscales of the cancer distress measure were associated with response to treatment.

Conclusions: Findings suggest that ART is an effective therapeutic intervention for reducing PTS symptoms and cancer distress among cancer survivors.

背景:估计有三分之一的癌症幸存者患有创伤后应激反应(PTS)症状。创伤后应激反应与高度的癌症困扰、焦虑和抑郁有关。目前几乎没有针对创伤后应激反应的循证治疗方法。加速解决疗法(ART)是一种以创伤为重点的心理疗法,在减轻非癌症患者的创伤后应激症状、心理困扰、焦虑和抑郁症状方面既安全又有效:这项单臂试点研究的目的是检验抗逆转录病毒疗法在缓解癌症幸存者创伤后应激症状、癌症困扰、抑郁症状和焦虑方面的初步疗效,并评估最有可能对抗逆转录病毒疗法产生反应的人群的基线特征。参与者接受了五次抗逆转录病毒疗法治疗,并在入组时、接受抗逆转录病毒疗法后立即以及接受抗逆转录病毒疗法后 30 天内对结果变量进行了评估。采用配对 t 检验来检验各时间点得分之间的差异。采用单变量线性回归法评估 PCL-5 评分从基线到 30 天后访视之间的关联及其他变量:结果:在 20 位癌症幸存者样本中,PTS 症状出现了统计学意义上的显著下降(p 结论:ART 是一种有效的治疗方法:研究结果表明,抗逆转录病毒疗法是减少癌症幸存者创伤后应激障碍症状和癌症困扰的有效治疗干预措施。
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来源期刊
Psycho‐Oncology
Psycho‐Oncology 医学-心理学
CiteScore
6.30
自引率
8.30%
发文量
220
审稿时长
3-8 weeks
期刊介绍: Psycho-Oncology is concerned with the psychological, social, behavioral, and ethical aspects of cancer. This subspeciality addresses the two major psychological dimensions of cancer: the psychological responses of patients to cancer at all stages of the disease, and that of their families and caretakers; and the psychological, behavioral and social factors that may influence the disease process. Psycho-oncology is an area of multi-disciplinary interest and has boundaries with the major specialities in oncology: the clinical disciplines (surgery, medicine, pediatrics, radiotherapy), epidemiology, immunology, endocrinology, biology, pathology, bioethics, palliative care, rehabilitation medicine, clinical trials research and decision making, as well as psychiatry and psychology. This international journal is published twelve times a year and will consider contributions to research of clinical and theoretical interest. Topics covered are wide-ranging and relate to the psychosocial aspects of cancer and AIDS-related tumors, including: epidemiology, quality of life, palliative and supportive care, psychiatry, psychology, sociology, social work, nursing and educational issues. Special reviews are offered from time to time. There is a section reviewing recently published books. A society news section is available for the dissemination of information relating to meetings, conferences and other society-related topics. Summary proceedings of important national and international symposia falling within the aims of the journal are presented.
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