Molecular pathogenesis of Cryptosporidium and advancements in therapeutic interventions.

IF 2.3 2区医学 Q2 PARASITOLOGY

Parasite Pub Date : 2025-01-01 Epub Date: 2025-02-04 DOI:10.1051/parasite/2025001

Yilong Lu, Xiaoning Zhang, Zhiyu Guan, Rui Ji, Fujun Peng, Chunzhen Zhao, Wei Gao, Feng Gao

引用次数: 0

Abstract

Cryptosporidiosis, caused by a Cryptosporidium infection, is a serious gastrointestinal disease commonly leading to diarrhea in humans. This disease poses a particular threat to infants, young children, and those with weakened immune systems. The treatment of cryptosporidiosis is challenging due to the current lack of an effective treatment or vaccine. Ongoing research is focused on understanding the molecular pathogenesis of Cryptosporidium and developing pharmacological treatments. In this review, we examine the signaling pathways activated by Cryptosporidium infection within the host and their role in protecting host epithelial cells. Additionally, we also review the research progress of chemotherapeutic targets against cryptosporidia-specific enzymes and anti-Cryptosporidium drugs (including Chinese and Western medicinal drugs), aiming at the development of more effective treatments for cryptosporidiosis.

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隐孢子虫的分子致病机理和治疗干预措施的进展。

隐孢子虫病是由隐孢子虫感染引起的一种严重的胃肠道疾病，通常导致人类腹泻。这种疾病对婴儿、幼儿和免疫系统较弱的人构成特别威胁。由于目前缺乏有效的治疗方法或疫苗，隐孢子虫病的治疗具有挑战性。正在进行的研究主要集中在了解隐孢子虫的分子发病机制和开发药物治疗。本文综述了隐孢子虫感染激活的宿主信号通路及其在保护宿主上皮细胞中的作用。此外，我们还综述了针对隐孢子虫特异性酶的化疗靶点和抗隐孢子虫药物（包括中西医药物）的研究进展，旨在开发更有效的隐孢子虫病治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Parasite 医学-寄生虫学

CiteScore

5.50

自引率

6.90%

发文量

审稿时长

3 months

期刊介绍： Parasite is an international open-access, peer-reviewed, online journal publishing high quality papers on all aspects of human and animal parasitology. Reviews, articles and short notes may be submitted. Fields include, but are not limited to: general, medical and veterinary parasitology; morphology, including ultrastructure; parasite systematics, including entomology, acarology, helminthology and protistology, and molecular analyses; molecular biology and biochemistry; immunology of parasitic diseases; host-parasite relationships; ecology and life history of parasites; epidemiology; therapeutics; new diagnostic tools. All papers in Parasite are published in English. Manuscripts should have a broad interest and must not have been published or submitted elsewhere. No limit is imposed on the length of manuscripts, but they should be concisely written. Papers of limited interest such as case reports, epidemiological studies in punctual areas, isolated new geographical records, and systematic descriptions of single species will generally not be accepted, but might be considered if the authors succeed in demonstrating their interest.