The correlation between vitamin B12 serum levels and migraine: a case-control study.

IF 1.7 4区医学 Q3 CLINICAL NEUROLOGY

Neurological Research Pub Date : 2025-03-01 Epub Date: 2025-02-04 DOI:10.1080/01616412.2025.2462735

Seham Elsaid Abdelsadek, Sara Ahmed Tahoun, Fathy Mahmoud Mansour, Mohammad Fathi Abdulsalam, Ali Mahmoud Ahmed

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引用次数: 0

Abstract

Objectives: Migraine represents the prevailing form of primary headache with no fully described etiology and pathophysiology. This study aimed to assess the association between vitamin B12 serum levels and both chronic and episodic migraine.

Patients and methods: This study was conducted as a case-control study, including 90 migraineurs, divided into 48 with episodic migraine and 42 with chronic migraine as the case group, and 90 matched healthy participants as the control group. The serum level of vitamin B12 was measured using enzyme-linked immunosorbent assay (ELISA) for all subjects. Its association with the Migraine Disability Assessment (MIDAS) scale and migraine attack severity, measured using the Visual Analog Scale (VAS), was analyzed.

Results: Migraineurs exhibited a notable reduction in serum vitamin B12 levels compared to the control group (243.97 ± 124.85 pg/ml vs. 302.69 ± 143.69 pg/ml, p = 0.014). Furthermore, chronic migraine patients had significantly lower serum vitamin B12 levels when compared to episodic migraine patients (202.7 ± 75.62 pg/ml vs. 269.17 ± 143.31 pg/ml, p = 0.026). A significant negative correlation was found between serum vitamin B12 levels and the severity of migraine attacks, as measured by the VAS (r = -0.407, p = 0.036).

Conclusion: The current study highlighted that vitamin B12 deficiency is highly associated with migraine and its severity. Further interventional research is highly recommended to investigate the potential causality of this association.

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维生素B12血清水平与偏头痛的相关性：一项病例对照研究。

目的：偏头痛代表了原发性头痛的主要形式，没有完全描述的病因和病理生理学。这项研究旨在评估维生素B12血清水平与慢性和发作性偏头痛之间的关系。患者和方法：本研究采用病例-对照研究，纳入90例偏头痛患者，分为48例发作性偏头痛患者和42例慢性偏头痛患者为病例组，90例匹配的健康参与者为对照组。采用酶联免疫吸附试验（ELISA）测定所有受试者血清维生素B12水平。分析其与偏头痛残疾评估（MIDAS）量表和偏头痛发作严重程度（使用视觉模拟量表（VAS）测量）的关联。结果：与对照组相比，偏头痛患者血清维生素B12水平显著降低（243.97±124.85 pg/ml vs. 302.69±143.69 pg/ml, p = 0.014）。此外，慢性偏头痛患者血清维生素B12水平明显低于发作性偏头痛患者（202.7±75.62 pg/ml vs. 269.17±143.31 pg/ml, p = 0.026）。通过VAS测量，血清维生素B12水平与偏头痛发作的严重程度呈显著负相关（r = -0.407, p = 0.036）。结论：目前的研究强调维生素B12缺乏与偏头痛及其严重程度高度相关。强烈建议进一步的介入研究来调查这种关联的潜在因果关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurological Research 医学-临床神经学

CiteScore

3.60

自引率

0.00%

发文量

116

审稿时长

5.3 months

期刊介绍： Neurological Research is an international, peer-reviewed journal for reporting both basic and clinical research in the fields of neurosurgery, neurology, neuroengineering and neurosciences. It provides a medium for those who recognize the wider implications of their work and who wish to be informed of the relevant experience of others in related and more distant fields. The scope of the journal includes: •Stem cell applications •Molecular neuroscience •Neuropharmacology •Neuroradiology •Neurochemistry •Biomathematical models •Endovascular neurosurgery •Innovation in neurosurgery.