Relationship of Neurotropin-3 Gene Polymorphism with Cognitive Impairment in Bipolar Disorder.

IF 1.9 Q3 PSYCHIATRY

Indian Journal of Psychological Medicine Pub Date : 2025-02-02 DOI:10.1177/02537176251314157

Muralidharan Monisha, Neha Keshri, Hanumanthappa Nandeesha, Vikas Menon

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引用次数: 0

Abstract

Background: Neurotropin-3 (NT-3), a marker of neural plasticity, is reported to be altered in bipolar disorder (BD). This study was designed to evaluate NT-3 gene polymorphism (rs 6489630, rs 6332, and rs 11063714) in BD and its association with disease severity and cognition.

Methods: The study included 176 BD cases and 176 controls. All the participants were tested for NT-3 polymorphism and plasma NT-3. ACE-III scores were used to analyze cognition.

Results: The NT-3 polymorphism (rs 6489630) was associated with cognitive impairment in BD (P = .010). The attention score was found to be decreased in the CT genotype (P = .028) when compared to the CC and TT genotypes of the rs6489630 variant. The visuospatial ability score was decreased in the GG genotype (P = .044) compared to the AG genotype of the rs11063714 variant. BD patients with the maniac episode showed a decrease in levels of Neurotrophin-3 in comparison to both the control group (P = .045) and the remission group (P = .017). Plasma NT-3 was associated with the YMRS (r = -0.221, P = .003), HDRS (r = 0.209, P = .005) and visuospatial ability score (r = 0.180, P = .017) in patients with BD.

Conclusion: Single nucleotide polymorphisms of NT-3 are associated with cognitive dysfunction in BD.

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来源期刊

Indian Journal of Psychological Medicine PSYCHOLOGY-

CiteScore

4.80

自引率

7.10%

发文量

116

审稿时长

12 weeks

期刊介绍： The Indian Journal of Psychological Medicine (ISSN 0253-7176) was started in 1978 as the official publication of the Indian Psychiatric Society South Zonal Branch. The journal allows free access (Open Access) and is published Bimonthly. The Journal includes but is not limited to review articles, original research, opinions, and letters. The Editor and publisher accept no legal responsibility for any opinions, omissions or errors by the authors, nor do they approve of any product advertised within the journal.