Relationship of Neurotropin-3 Gene Polymorphism with Cognitive Impairment in Bipolar Disorder.

IF 1.9 Q3 PSYCHIATRY

Indian Journal of Psychological Medicine Pub Date : 2025-02-02 DOI:10.1177/02537176251314157

Muralidharan Monisha, Neha Keshri, Hanumanthappa Nandeesha, Vikas Menon

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引用次数: 0

Abstract

Background: Neurotropin-3 (NT-3), a marker of neural plasticity, is reported to be altered in bipolar disorder (BD). This study was designed to evaluate NT-3 gene polymorphism (rs 6489630, rs 6332, and rs 11063714) in BD and its association with disease severity and cognition.

Methods: The study included 176 BD cases and 176 controls. All the participants were tested for NT-3 polymorphism and plasma NT-3. ACE-III scores were used to analyze cognition.

Results: The NT-3 polymorphism (rs 6489630) was associated with cognitive impairment in BD (P = .010). The attention score was found to be decreased in the CT genotype (P = .028) when compared to the CC and TT genotypes of the rs6489630 variant. The visuospatial ability score was decreased in the GG genotype (P = .044) compared to the AG genotype of the rs11063714 variant. BD patients with the maniac episode showed a decrease in levels of Neurotrophin-3 in comparison to both the control group (P = .045) and the remission group (P = .017). Plasma NT-3 was associated with the YMRS (r = -0.221, P = .003), HDRS (r = 0.209, P = .005) and visuospatial ability score (r = 0.180, P = .017) in patients with BD.

Conclusion: Single nucleotide polymorphisms of NT-3 are associated with cognitive dysfunction in BD.

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神经tropin-3基因多态性与双相情感障碍患者认知功能障碍的关系

背景：神经tropin-3 （NT-3）是神经可塑性的标志，据报道在双相情感障碍（BD）中发生改变。本研究旨在评估BD患者NT-3基因多态性（rs 6489630、rs 6332和rs 11063714）及其与疾病严重程度和认知的关系。方法：选取176例BD患者和176例对照组。所有参与者都进行了NT-3多态性和血浆NT-3检测。ACE-III评分用于认知分析。结果：NT-3多态性（rs 6489630）与双相障碍患者认知功能障碍相关（P = 0.010）。与rs6489630变异的CC和TT基因型相比，CT基因型的注意力得分降低（P = 0.028）。与rs11063714基因型的AG基因型相比，GG基因型的视觉空间能力得分降低（P = 0.044）。与对照组（P = 0.045）和缓解组（P = 0.017）相比，伴有狂躁发作的BD患者的神经营养因子-3水平均有所下降。血浆NT-3与BD患者YMRS （r = -0.221, P = 0.003）、HDRS （r = 0.209, P = 0.005）、视觉空间能力评分（r = 0.180, P = 0.017）相关。结论：NT-3单核苷酸多态性与BD患者认知功能障碍相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian Journal of Psychological Medicine PSYCHOLOGY-

CiteScore

4.80

自引率

7.10%

发文量

116

审稿时长

12 weeks

期刊介绍： The Indian Journal of Psychological Medicine (ISSN 0253-7176) was started in 1978 as the official publication of the Indian Psychiatric Society South Zonal Branch. The journal allows free access (Open Access) and is published Bimonthly. The Journal includes but is not limited to review articles, original research, opinions, and letters. The Editor and publisher accept no legal responsibility for any opinions, omissions or errors by the authors, nor do they approve of any product advertised within the journal.