Electron transfer-chemical reaction-electron transfer study of dobutamine, isoprenaline, droxidopa, and methyldopa with carbon nanotube-based electrode

IF 1.8 4区化学 Q3 CHEMISTRY, ANALYTICAL

Analytical Sciences Pub Date : 2025-02-04 DOI:10.1007/s44211-025-00725-9

Yoka Shu, Mei Kadowaki, Hitoshi Muguruma

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Abstract

The electrochemical behavior of catecholamines involves an electron transfer-chemical reaction-electron transfer (ECE) mechanism, characterized by two reversible redox reactions interspersed with an irreversible chemical reaction. Previously, we reported ECE studies on dopamine and norepinephrine. In this work, we extend our study to catecholamine drugs including dobutamine, isoprenaline, droxidopa, and methyldopa, using a carbon nanotube electrode. These drugs exhibit significantly faster intramolecular cyclization rates compared to dopamine and norepinephrine. This accelerated cyclization is attributed to (1) the presence of more complex substituents in these drugs and (2) the fact that dobutamine and isoprenaline are secondary amines, while dopamine and norepinephrine are primary amines. This study enhances the understanding of catecholamines and offers valuable insights for the development of novel electrochemical sensing strategies for catecholamine drugs.

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使用碳纳米管电极对多巴酚丁胺、异丙肾上腺素、屈昔多巴和甲基多巴进行电子转移-化学反应-电子转移研究。

儿茶酚胺的电化学行为涉及电子转移-化学反应-电子转移（ECE）机制，其特征是两个可逆氧化还原反应穿插着一个不可逆化学反应。之前，我们报道了多巴胺和去甲肾上腺素的ECE研究。在这项工作中，我们将研究扩展到儿茶酚胺类药物，包括多巴酚丁胺、异丙肾上腺素、羟多巴和甲基多巴，使用碳纳米管电极。与多巴胺和去甲肾上腺素相比，这些药物表现出明显更快的分子内环化速率。这种加速环化的原因是：(1)这些药物中存在更复杂的取代基；(2)多巴酚丁胺和异丙肾上腺素是仲胺，而多巴胺和去甲肾上腺素是初级胺。该研究增强了对儿茶酚胺的认识，并为儿茶酚胺类药物的新型电化学传感策略的开发提供了有价值的见解。

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来源期刊

Analytical Sciences 化学-分析化学

CiteScore

2.90

自引率

18.80%

发文量

232

审稿时长

1 months

期刊介绍： Analytical Sciences is an international journal published monthly by The Japan Society for Analytical Chemistry. The journal publishes papers on all aspects of the theory and practice of analytical sciences, including fundamental and applied, inorganic and organic, wet chemical and instrumental methods. This publication is supported in part by the Grant-in-Aid for Publication of Scientific Research Result of the Japanese Ministry of Education, Culture, Sports, Science and Technology.