Front Cover: Protein Quakes in Redox Metalloenzymes: Clues to Molecular Enzyme Conductivity Triggered by Binding of Small Substrate Molecules (ChemistryOpen 12/2024)
Henrik Bohr, Irene Shim, Jens Ulstrup, Xinxin Xiao
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引用次数: 0
Abstract
Redox metalloenzymes often show no electrochemistry, while the enzyme substrate triggers electrocatalysis. For example two-centre Cu nitrite reductase in the biological nitrogen cycle shows voltammetry only when NO2- is present. NO2- also triggers STM conductivity, while AFM discloses major conformational expansion.The front cover offers an ab initio quantum chemical rationale based on 740-atom enzyme fragments. NO2- induces conformational reorganization throughout the protein and frontier orbital delocalization strongly promoting electronic conductivity. More information can be found in the Research Article by Jens Ulstrup and co-workers (DOI: 10.1002/open.202400190).
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