Graphene oxide functionalized halloysite nanotubes for voltammetric determination of psychoactive drug from alcoholic and non-alcoholic drinks

IF 5.9 3区材料科学 Q2 CHEMISTRY, PHYSICAL

FlatChem Pub Date : 2025-01-01 DOI:10.1016/j.flatc.2024.100794

Gurpreet Kaur , Garima , Varnika Prakash , Swati Gupta , Manoj Kumar Chaudhary , S.K. Mehta , Shweta Sharma

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Abstract

In context to the widespread misuse of benzodiazepines, a novel platform based on the graphene oxide functionalized halloysite nanotubes (HNT/GO) has been introduced for the electrochemical detection of commonly abused date rape drug-nitrazepam (NZP). In this work, HNT/GO composite has been synthesized via simple stirring method and the fabricated materials were characterized by using combination of spectroscopic, microscopic, X-ray and voltammetric techniques i.e., FTIR, FE-SEM-EDX, TEM, XRD, XPS and Cyclic voltammetry. Surface modification of HNTs with GO increased the synergistic properties of both the materials for electrochemical sensing of nitrazepam. Specifically, HNTs provided high surface area, nanotubular morphology with unique surface functionalities and GO added electron rich functional sites. Combination of HNTs with GO significantly increased electrochemical active surface area from 0.06 to 0.236 cm² which increased electron transfer on the surface of electrode towards electrochemical reduction of nitrazepam. The developed sensor showed excellent electrochemical response for nitrazepam detection with a linear dynamic range of 0.16–150 μM and limit of detection 0.79 μM. The proposed sensor has successfully been employed for electrochemical determination of nitrazepam in non-alcoholic and alcoholic drinks without any sample pre-treatment.

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氧化石墨烯功能化哈洛石纳米管用于伏安法测定酒精和非酒精饮料中的精神活性药物

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来源期刊

FlatChem Multiple-

CiteScore

8.40

自引率

6.50%

发文量

104

审稿时长

26 days

期刊介绍： FlatChem - Chemistry of Flat Materials, a new voice in the community, publishes original and significant, cutting-edge research related to the chemistry of graphene and related 2D & layered materials. The overall aim of the journal is to combine the chemistry and applications of these materials, where the submission of communications, full papers, and concepts should contain chemistry in a materials context, which can be both experimental and/or theoretical. In addition to original research articles, FlatChem also offers reviews, minireviews, highlights and perspectives on the future of this research area with the scientific leaders in fields related to Flat Materials. Topics of interest include, but are not limited to, the following: -Design, synthesis, applications and investigation of graphene, graphene related materials and other 2D & layered materials (for example Silicene, Germanene, Phosphorene, MXenes, Boron nitride, Transition metal dichalcogenides) -Characterization of these materials using all forms of spectroscopy and microscopy techniques -Chemical modification or functionalization and dispersion of these materials, as well as interactions with other materials -Exploring the surface chemistry of these materials for applications in: Sensors or detectors in electrochemical/Lab on a Chip devices, Composite materials, Membranes, Environment technology, Catalysis for energy storage and conversion (for example fuel cells, supercapacitors, batteries, hydrogen storage), Biomedical technology (drug delivery, biosensing, bioimaging)