Impregnation of non-steroidal anti-inflammatory drugs (ibuprofen and ketoprofen) onto mesoporous silica SBA-15 using supercritical CO2

IF 7.2 2区工程技术 Q1 CHEMISTRY, MULTIDISCIPLINARY

Journal of CO2 Utilization Pub Date : 2025-02-01 DOI:10.1016/j.jcou.2025.103022

Kairi Yamamoto, Ikuo Ushiki

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引用次数: 0

Abstract

Ibuprofen and ketoprofen were impregnated onto SBA-15 type mesoporous silica using the supercritical fluid deposition (SCFD) method with supercritical carbon dioxide (CO₂) as the solvent at temperatures ranging from 313 K to 343 K and a pressure of 15 MPa. The prepared samples were evaluated using electron microscopy, nitrogen adsorption measurements, infrared spectroscopy, and thermogravimetric analysis. The impregnation of the drugs into the mesoporous silica pores was confirmed by nitrogen adsorption experiments. The amount of drug impregnation was found to depend on both the drug species and the type of mesoporous silica. It was suggested that the solubility in supercritical CO₂ played a dominant role for the drug species. There was virtually no effect of temperature on the amount of drug impregnation, which may be attributed to the interplay between the solubility of supercritical CO₂ and the adsorption equilibrium of the drug on mesoporous silica under supercritical CO₂ conditions.

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来源期刊

Journal of CO2 Utilization CHEMISTRY, MULTIDISCIPLINARY-ENGINEERING, CHEMICAL

CiteScore

13.90

自引率

10.40%

发文量

406

审稿时长

2.8 months

期刊介绍： The Journal of CO2 Utilization offers a single, multi-disciplinary, scholarly platform for the exchange of novel research in the field of CO2 re-use for scientists and engineers in chemicals, fuels and materials. The emphasis is on the dissemination of leading-edge research from basic science to the development of new processes, technologies and applications. The Journal of CO2 Utilization publishes original peer-reviewed research papers, reviews, and short communications, including experimental and theoretical work, and analytical models and simulations.