An efficient approach to indolizine-3-carboxylates via Cu(I)-promoted decarboxylative cycloaddition of alkenoic acids

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-02-01 DOI:10.1016/j.tet.2024.134423

Binbin Zhou , Huacan Xv , Ke Zhang , Xv Han , Shuhao Liu , Jiayu He , Jinwei Sun , Yuling Li , Yun Liu

引用次数: 0

Abstract

A practical synthesis of indolizine-3-carboxylates has been developed via copper-promoted reaction of alkenoic acids with bromoesters and pyridines using air as the terminal oxidant. In this reaction, carboxyl group acts as a traceless substituent to activate carbon-carbon double bond. By this protocol, we have successfully obtained indolizine-3-carboxylates with aryl or alkyl group at 1-position or 2-position of indolizine motif. This protocol features advantages of simple reaction conditions as well as broad substituents kinds.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.