Cu(II) nano-MOF catalyzed synthesis of 4H-Chromene derivatives as cholinesterase inhibitors

Abstract

Nanoscale metal–organic frameworks have attracted a lot of attention lately for use in heterogeneous catalytic applications, considering their strong catalytic activity. In this research article, a new Cu(II) nano-MOF is synthesized, that functions as an efficient heterogeneous and recyclable catalyst in the synthesis of 4H-chromene derivatives. The distinctive features of the presented synthetic strategy include high yield of the products, shorter reaction time compared to already reported methods, mild and environmentally friendly reaction conditions. Additionally, the potential of the synthesized 4H-chromene derivatives to elegantly inhibit two crucial target enzymes, acetylcholinesterase and butyrylcholinesterase, in the quest to combat the relentless progression of Alzheimer's disease (AD) is explored.