Diphenhydramine: It is time to say a final goodbye

IF 3.9 2区医学 Q2 ALLERGY

World Allergy Organization Journal Pub Date : 2025-02-01 DOI:10.1016/j.waojou.2025.101027

James H. Clark, MD , Eli O. Meltzer, MD , Robert M. Naclerio, MD

引用次数: 0

Abstract

Diphenhydramine, once a pioneering antihistamine, is now overshadowed by second-generation antihistamines with similar efficacy and fewer adverse effects. Current data suggest that the adverse side-effect profile of diphenhydramine is higher among children and older adults. This has led to countries such as Germany and Sweden restricting access to first-generation antihistamines and societal guidelines advocating for the use of second-generation antihistamines. Despite its well-documented problematic therapeutic ratio, diphenhydramine remains available in over 300 formulations, most of which are over-the-counter.

Based on a comprehensive evaluation of practice patterns and the prevalence and incidence of adverse clinical events, we believe that diphenhydramine has reached the end of its life cycle, and in its class of therapies it is a relatively greater public health hazard. We recommend it should no longer be widely prescribed or continue to be readily available over the counter.

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苯海拉明：是时候说最后的再见了

苯海拉明，曾经是抗组胺药的先驱，现在被第二代抗组胺药所掩盖，后者疗效相似，副作用更少。目前的数据表明，苯海拉明的不良副作用在儿童和老年人中较高。这导致德国和瑞典等国限制获得第一代抗组胺药，而社会指南则倡导使用第二代抗组胺药。尽管有充分的证据证明苯海拉明的治疗比例存在问题，但仍有300多种配方可供使用，其中大多数是非处方药。基于对实践模式和不良临床事件的患病率和发生率的综合评估，我们认为苯海拉明已达到其生命周期的终点，在其治疗类别中，它对公共卫生的危害相对较大。我们建议它不应再被广泛开处方或继续在柜台上随时可用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World Allergy Organization Journal Immunology and Microbiology-Immunology

CiteScore

9.10

自引率

5.90%

发文量

审稿时长

9 weeks

期刊介绍： The official pubication of the World Allergy Organization, the World Allergy Organization Journal (WAOjournal) publishes original mechanistic, translational, and clinical research on the topics of allergy, asthma, anaphylaxis, and clincial immunology, as well as reviews, guidelines, and position papers that contribute to the improvement of patient care. WAOjournal publishes research on the growth of allergy prevalence within the scope of single countries, country comparisons, and practical global issues and regulations, or threats to the allergy specialty. The Journal invites the submissions of all authors interested in publishing on current global problems in allergy, asthma, anaphylaxis, and immunology. Of particular interest are the immunological consequences of climate change and the subsequent systematic transformations in food habits and their consequences for the allergy/immunology discipline.