Hot melt extrusion assisted additive manufacturing of mixed polymeric 3D printed metoprolol succinate extended-release tablets for controlled oral drug delivery

IF 3.8 Q2 CHEMISTRY, PHYSICAL
Shubham Ghatole , Jannu Dilip , Makka Krupali Ashokbhai , Himanshu Vishwakarma , Subham Banerjee , Santanu Kaity
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引用次数: 0

Abstract

This study introduces an innovative methodology for fabricating extended-release metoprolol succinate (MS) tablets through the integration of Soluplus® and hydroxypropyl methylcellulose acetate succinate (HPMCAS) polymers, employing hot-melt extrusion (HME) and additive manufacturing technology. A carefully optimized polymer-plasticizer combination facilitated the production of extrudable filaments, which were subsequently used in three-dimensional printing (3DP) tablets via fused deposition modeling (FDM). The filaments were comprehensively characterized using tensile strength assessment, Fourier-transform infrared spectroscopy (FT-IR), and X-ray diffraction (XRD). At the same time, micro-computed tomography (µCT) provided detailed analysis of the 3D-printed tablets. Filaments incorporating 10 % w/w citric acid as a plasticizer exhibited enhanced mechanical robustness, with tensile strength reaching 5.19 N, strain elongation of 29.2 %, and was found suitable for the fabrication of tablet dosage form with acceptable quality. Drug release , assessed in phosphate buffer at pH 6.8, revealed a controlled release profile, with 70 % of the active pharmaceutical ingredient (API) released over 6 h These results show the promise of using such techniques as platform technology for delivering similar categories of APIs. This developmental pathway can also be used for the fabrication of personalized medicines with adjustable drug release profiles.
热熔挤压辅助增材制造混合聚合物3D打印琥珀酸美托洛尔控释片
本研究介绍了一种创新的方法,通过将Soluplus®和羟丙基乙酸琥珀酸羟甲基纤维素(HPMCAS)聚合物整合,采用热熔挤出(HME)和增材制造技术,制造琥珀酸美托洛尔(MS)缓释片。经过精心优化的聚合物增塑剂组合促进了可挤压长丝的生产,随后通过熔融沉积建模(FDM)将其用于三维打印(3DP)片剂。利用拉伸强度评估、傅里叶变换红外光谱(FT-IR)和x射线衍射(XRD)对纤维进行了综合表征。同时,微计算机断层扫描(µCT)提供了3d打印片剂的详细分析。添加10%柠檬酸作为增塑剂的长丝具有增强的机械坚固性,抗拉强度达到5.19 N,应变伸长率为29.2%,适合制作片剂剂型,质量合格。在pH为6.8的磷酸盐缓冲液中评估药物释放,显示了一个可控的释放概况,70%的活性药物成分(API)在6小时内释放。这些结果表明,使用平台技术等技术可以提供类似类别的API。这种发展途径也可用于制造具有可调节药物释放谱的个性化药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Chemical Physics Impact
Chemical Physics Impact Materials Science-Materials Science (miscellaneous)
CiteScore
2.60
自引率
0.00%
发文量
65
审稿时长
46 days
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