Delving into the therapeutic prospects of desmostachya bipinnata (L.) in the context of polycystic ovary syndrome (PCOS): A comprehensive review

Q3 Pharmacology, Toxicology and Pharmaceutics

Phytomedicine Plus Pub Date : 2025-02-01 DOI:10.1016/j.phyplu.2025.100741

Sarthak Mishra, Payal Mittal

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Abstract

Background

PCOS, a prevalent endocrine condition in reproductive years, exhibits irregular ovulation, polycystic ovaries, insulin resistance, and elevated androgen levels. Desmostachya bipinnata (L.), Poaceae known as "Kusha," is a sacred grass integral to Vedic rituals, serving as a rich source of bioactive elements.

Purpose

This review focused on the bioactive compounds of D. Bipinnata which have shown various pharmacological action. We also focus on the phytochemical and pharmacological studies of D. Bipinnata. The present review is an effort to gather and consolidate the most recent information available on D. Bipinnata.

Material and Methods

Reference searches were achieved from various sources along with Google Scholar, Science Direct, Scopus, PubMed, and Springer with the keywords “PCOS”, “Hyperandrogenism”, “Therapeutic prospects”, “Herbal remedies”, “Bioactive compounds” in the text.

Result

The review compiles traditional and pharmacological uses of a plant rich in antioxidants, flavonoids, alkaloids, terpenoids, and sterols. Traditionally, the herb and root have treated various illnesses. Research highlights its broad pharmacological properties, such as antipyretic, analgesic, antidiarrheal, menorrhagia, and hepatoprotective.

Conclusion

Desmostachya bipinnata (L.) shows promise for PCOS management due to its rich content of bioactive compounds, including quercetin, linoleic acid, stigmasterol, Camphene, coumarins, and terpenes known for PCOS treatment. Despite these findings, additional clinical studies are required to validate its efficacy. This review delves into PCOS epidemiology, pathophysiology, and therapeutic potential, spotlighting D. bipinnata as a potential herbal solution for PCOS, pending additional research.

Abstract Image