Finger roots (Uvaria chemea) and African greenheart (Cylicodiscus gabunensis): Alternative potent therapy to sildenafil in erectile dysfunction

Q3 Pharmacology, Toxicology and Pharmaceutics
Etukudo Okon Jimmy , Grace Edet Bassey , Abijah Ekwere , Udoh Idorenyin Umoh , Adeyemi Fatai Odetayo , Udoh Nsikan Malachy
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Abstract

Background and aim

Erectile dysfunction (ED) is a prevalent condition affecting men worldwide, characterized by the inability to achieve or maintain an erection sufficient for sexual intercourse. Traditional herbal remedies, rooted in cultural practices, have been explored as alternative therapies for ED, and this study focuses on Uvara chemea and Cylicodiscus gabunensis, two plants with reported medicinal properties, as potential alternatives to sildenafil, a standard pharmaceutical for ED.

Experimental procedure

Forty male Wistar rats were randomly divided into five groups: control (treated with distilled water), low, medium, and high doses (treated with 61.23, 122.47, and 183.71 mg/kg each of Uvara chemea and Cylicodiscus gabunensis respectively), and a positive control group (treated with sildenafil citrate). The rats were treated for 21 days, and their erectile responses were estimated

Results

Significant improvements in erectile responses were observed in rats treated with Uvara chemea and Cylicodiscus gabunensis extracts compared to the control group. When compared to sildenafil citrate, the extracts showed comparable effects in most parameters, with a significant disparity noted in intromission frequency at low and high dosages. Strikingly, there was no significant difference between the extracts treated animals and their counterparts treated with sildenafil citrate.

Conclusion

Uvara chemea and Cylicodiscus gabunensis extracts demonstrated potential in ameliorating erectile dysfunction in rats, suggesting their viability as alternative or complementary therapeutic options to sildenafil citrate. Further investigations are necessary to elucidate the underlying mechanisms of action, determine optimal dosages, and evaluate the long-term safety profiles of these herbal extracts for potential human applications.
指根(Uvaria chemea)和非洲绿心(Cylicodiscus gabunensis):西地那非治疗勃起功能障碍的有效替代疗法
背景和目的勃起功能障碍(ED)是影响全球男性的一种普遍疾病,其特征是无法达到或维持足以进行性交的勃起。植根于文化实践的传统草药疗法已经被探索作为ED的替代疗法,本研究的重点是Uvara chemea和Cylicodiscus gabunensis这两种据报道具有药用价值的植物,作为ED的标准药物西地那非的潜在替代品。实验过程40只雄性Wistar大鼠随机分为五组:对照组(用蒸馏水处理)、低、中、高剂量组(分别用61.23、122.47和183.71 mg/kg的Uvara chemea和Cylicodiscus gabunensis处理)和阳性对照组(用枸橼酸西地那非处理)。结果:与对照组相比,经乌瓦拉化学和加本花青花提取物处理的大鼠勃起反应有显著改善。当与枸橼酸西地那非比较时,提取物在大多数参数上显示出相当的效果,在低剂量和高剂量时,在渗透频率上存在显着差异。引人注目的是,提取物处理的动物和用柠檬酸西地那非处理的动物之间没有显著差异。结论uvara化学制剂和环铁蓟提取物具有改善大鼠勃起功能障碍的作用,可作为枸橼酸西地那非的替代或补充治疗方案。需要进一步的研究来阐明潜在的作用机制,确定最佳剂量,并评估这些草药提取物对潜在人类应用的长期安全性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Phytomedicine Plus
Phytomedicine Plus Medicine-Complementary and Alternative Medicine
CiteScore
3.70
自引率
0.00%
发文量
178
审稿时长
81 days
期刊介绍:
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