Unveiling potential biomarkers and associated health risks of chronic experimental exposure to environmentally relevant concentration of metalaxyl: An untargeted metabolomics approach

IF 5.4 Q2 ENGINEERING, ENVIRONMENTAL

Journal of hazardous materials advances Pub Date : 2025-02-01 DOI:10.1016/j.hazadv.2025.100615

Nasreen Nazar , Niladri Sekhar Chatterjee

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Abstract

The aquatic ecosystem elemental for global biodiversity and human sustenance confronts enduring threats from pollutants, notably pesticides. Metalaxyl, a prevalent agrochemical has garnered attention due to its extensive application and potential endocrine-disrupting characteristics. This study has utilized an untargeted metabolomics approach employing UHPLC-Q-Orbitrap MS, to evaluate the metabolic changes associated with chronic experimental exposure (60 days) to Metalaxyl at an environmentally relevant concentration (25 ng/g) using Wistar albino rats. The results demonstrated notable variations in phosphatidylethanolamines, amino acid profiles, and vitamins, suggesting them as potential biomarkers to elucidate the influence of this environmental contaminant on biological systems. Furthermore, the pathway analysis revealed significant alterations in steroid biosynthesis, citric acid (TCA) cycle, Phenylalanine, tyrosine, and tryptophan biosynthesis, purine, and pyrimidine metabolisms. These results on the health implications of Metalaxyl offer valuable insights into its ecotoxicological effects and associated health risks. They also uncover these contaminants' profound and far-reaching impact on biological pathways by providing invaluable insight into their disruptive and influential nature.

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