Monitoring the follow-up of autoimmune chronic atrophic gastritis using parietal cell antibodies and markers of gastric function

IF 4.7 Q2 IMMUNOLOGY
Maria Piera Panozzo , Antonio Antico , Nicola Bizzaro
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Abstract

Increased interest in the pathogenesis and the evolution of autoimmune chronic atrophic gastritis (A-CAG) has led to the search for serological markers that can be used to detect changes in the gastric mucosa at an early stage and to monitor the course of the disease. Parietal cell autoantibodies have been proposed as suitable immunological markers of atrophic damage, as they can be detected in the serum when symptoms of gastritis are not yet present. However, the utility of measuring only the level of parietal cell autoantibodies in the follow-up of A-CAG does not appear to suffice. Recent evidence has suggested that, in monitoring A-CAG, parietal cell antibodies should be associated with an evaluation of gastric function through biochemical and hormonal tests, such as pepsinogens and gastrin 17. This integrated approach will allow for the more effective real-time monitoring of the state of the gastric mucosa. As A-CAG is a progressive disorder associated with an increased risk of gastric cancer and neuroendocrine tumors, the precise follow-up of patients with gastric atrophy needs to be better defined. Further longitudinal studies in large cohorts must be performed with long-term follow-up.
利用壁细胞抗体和胃功能标志物监测自身免疫性慢性萎缩性胃炎的随访
对自身免疫性慢性萎缩性胃炎(A-CAG)的发病机制和演变的兴趣增加,导致寻找可用于早期检测胃粘膜变化和监测疾病进程的血清学标志物。壁细胞自身抗体被认为是萎缩性损伤的合适免疫学标记物,因为当胃炎症状尚未出现时,它们可以在血清中检测到。然而,在A-CAG的随访中,仅测量壁细胞自身抗体水平的效用似乎是不够的。最近的证据表明,在监测A-CAG时,壁细胞抗体应与通过生化和激素测试(如胃蛋白酶原和胃泌素17)评估胃功能相关。这种综合方法将允许更有效的实时监测胃粘膜的状态。由于a - cag是一种进行性疾病,与胃癌和神经内分泌肿瘤的风险增加有关,因此对胃萎缩患者的精确随访需要更好的定义。进一步的大队列纵向研究必须进行长期随访。
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来源期刊
Journal of Translational Autoimmunity
Journal of Translational Autoimmunity Medicine-Immunology and Allergy
CiteScore
7.80
自引率
2.60%
发文量
33
审稿时长
55 days
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