Correlation of the expression of the interleukin-1 signaling pathway with prognostic factors in oral squamous cell carcinoma: an immunohistochemical study

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-02-01 DOI:10.1016/j.oooo.2024.10.106

Felipe Martins Silveira , Sven Eric Niklander , Wilfredo Alejandro Gonzalez Arriagada , René Martínez-Flores , Ronell Eduardo Bologna-Molina

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引用次数: 0

Abstract

Objective

Interleukin (IL)-1 comprises a family of inflammation-regulating cytokines that govern various innate immune processes. This study aims to evaluate the immunohistochemical expression of IL-1 family members in oral squamous cell carcinoma (OSCC) and elucidate the association of their expression with clinicopathological features.

Methods

Immunohistochemical expressions of IL-1α, IL-1β, IL-1RA, and IL-1R1 were assessed in the parenchyma (invasion front) of 44 OSCC resections. Immunoreactivity was evaluated in association with histologic grade, perineural invasion, recurrence, and clinical staging of OSCC cases. The χ² test was employed to correlate expression levels of IL-1 family members with clinicopathologic variables, and Cox regression was used to identify independent risk factors related to poor 5-year survival.

Results

Tumor islands at the invasion front of all evaluated OSCC cases were positive, showing varying degrees of immunoreactivity for IL-1α, IL-1β, IL-1RA, and IL-1R1, with a greater proportion of cases exhibiting high IL-1RA expression (62.5%). Low IL-1α immunoreactivity demonstrated a statistically significant association with increased recurrence (P = .007) and less-differentiated tumors (P = .036). No significant association of other IL-1 family members with any evaluated prognostic factors was observed.

Conclusions

The results suggest that reduced tissue expression of IL-1α is associated with increased recurrence and less-differentiated OSCC cases. The role of pro-inflammatory factors in the IL-1 signaling pathway appears to be more crucial in etiopathogenesis than in the prognostic factors of OSCC.

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来源期刊

Oral Surgery Oral Medicine Oral Pathology Oral Radiology DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.80

自引率

6.90%

发文量

1217

审稿时长

2-4 weeks

期刊介绍： Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology is required reading for anyone in the fields of oral surgery, oral medicine, oral pathology, oral radiology or advanced general practice dentistry. It is the only major dental journal that provides a practical and complete overview of the medical and surgical techniques of dental practice in four areas. Topics covered include such current issues as dental implants, treatment of HIV-infected patients, and evaluation and treatment of TMJ disorders. The official publication for nine societies, the Journal is recommended for initial purchase in the Brandon Hill study, Selected List of Books and Journals for the Small Medical Library.