Eating disorders and cardiovascular outcomes: A systematic review with meta-analysis

IF 2.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry Pub Date : 2025-01-28 DOI:10.1016/j.ejpsy.2024.100274

Cristiane Buzanello-Donin , Monica Augusta Mombelli , Márcia Rosângela Buzanello , Clenise Maria Reis Capellani dos Santos , Cassia Cristina Paes de Almeida , Rogério da Luz , Miguel Morita Fernandes da Silva

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引用次数: 0

Abstract

Background and objective

To conduct a literature review to assess the association between eating disorders (ED), cardiovascular outcomes and all-cause mortality.

Methods

Observational studies that presented a measure of association between mortality (or cardiac outcomes) and EDs in adult or adolescent patients were included. The databases PubMed, Web of Science, EMBASE, Livivo, Scopus, PsycINFO and Lilacs were consulted. The random effect was adopted to group the findings of the primary studies in the meta-analysis using the Hazzard Ratio (HR) as a measure of association.

Results

The meta-analysis with 50,263 patients with ED showed a higher risk of mortality from all causes in patients compared to controls. The associated risk of death from all causes was higher with anorexia (AN) compared to other ED (AN: HR 5.38; 95 %CI 4.42 to 6.56; binge ED: HR 2.48; 95 %CI 1.13 to 5.46; bulimia: HR 2.21; 95 %CI 1.70 to 2.87). Additionally, one study demonstrated an association between bulimia and an increased risk of developing cardiovascular disease (HR 4.25; 95 %CI 2.98 to 6.07) and another study showed a higher risk of cardiovascular events in people with bulimia than in healthy controls (HR 1.4; 95 %CI 0.7 to 2.8). Finally, a higher risk of cardiovascular events in people with AN (HR 10.4; 95 %CI 2.6 to 41.6) was demonstrated in one study, when compared to healthy controls.

Conclusions

There is an association between EDs and all-cause mortality, with AN being associated with the highest risk, followed by binge ED and bulimia.

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来源期刊

European Journal of Psychiatry PSYCHIATRY-

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

43 days

期刊介绍： The European journal of psychiatry is a quarterly publication founded in 1986 and directed by Professor Seva until his death in 2004. It was originally intended to report “the scientific activity of European psychiatrists” and “to bring about a greater degree of communication” among them. However, “since scientific knowledge has no geographical or cultural boundaries, is open to contributions from all over the world”. These principles are maintained in the new stage of the journal, now expanded with the help of an American editor.