New eremophilane-type sesquiterpenoid and new chromanone isolated from marine derived fungus Humicola sp. GXIMD02070

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-02-01 DOI:10.1016/j.phytol.2024.11.011

Quan Teng , Qiuxia Nong , Xin Jin , Chenghai Gao , Along Zhang , Nannan Xing , Xianqiang Chen

引用次数: 0

Abstract

Chemical investigation of a marine-derived fungus Humicola sp. GXIMD02070 resulted in the isolation of one new eremophilane-type sesquiterpenoid (1), one new chromanone analogue (2), and three previously described metabolites, namely chaetosemin D (3), butyrolactone I (4), and isoochracinic acid (5). Their structures were elucidated by comprehensive analyses of the spectroscopic methods, quantum chemical calculation of NMR, and electronic circular dichroism (ECD) calculations. Compounds 1 and 2 exhibited inhibitory effects on NO production with EC₅₀ value of 82.04 ± 0.12 μM and 100.2 ± 0.13 μM, respectively, indicating moderate anti-inflammatory activity.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.