Sesquiterpene glycosides from Sapindus mukorossi

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-02-01 DOI:10.1016/j.phytol.2025.01.001

Le Thi Vien , Do Hoang Anh , Pham Thi Mai Huong , Pham Thi Cham , Ninh Thi Ngoc , Nguyen Mai Anh , Nguyen The Cuong , Tran Thi Hong Hanh , Nguyen Xuan Cuong

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引用次数: 0

Abstract

A phytochemical investigation of Sapindus mukorossi pericarps yielded six acyclic sesquiterpene glycosides (1−6), including three new compounds, named mukuroziosides A−C (1−3). Structural characterization was confirmed by an extensive analysis of 1D and 2D NMR and HR-ESI-QTOF mass spectra. Notably, compound 4 was isolated from natural sources for the first time. The antibacterial effects of all compounds were evaluated against six bacterial strains: Enterococcus faecalis (ATCC299212), Staphylococcus aureus (ATCC25923), Bacillus cereus (ATCC14579), Escherichia coli (ATCC25922), Pseudomonas aeruginosa (ATCC27853), and Salmonella enterica (ATCC13076). All compounds were demonstrated minimum inhibitory concentration of >400 μM, indicating inactivity against these bacterial strains.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.