A new diterpenoid alkaloid from the Aconitum scaposum

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-02-01 DOI:10.1016/j.phytol.2024.12.002

Cheng-En Fu , Gui-Fang Li , Guo-Qing Sun , Shuai Huang , Lin Chen , Xian-Li Zhou

引用次数: 0

Abstract

A new atisine-type C₂₀-diterpenoid alkaloid (scaposum A) and twelve known compounds (2–13) were isolated from the dried tuberous roots of Aconitum scaposum Franch and characterized by spectroscopic analyses such as IR, HR-ESI-MS and NMR. All compounds were isolated from this plant for the first time and tested for their anti-proliferative effects on Sf9 and 4T1 cells, inhibition of NO production from LPS-induced BV2 and RAW264.7 cells, and inhibition of acetylcholinesterase from Electrophorus electricus (eeAChE). The results showed that compounds 8 (81.26 %) and 11 (80.99 %) exhibited anti-proliferative effects on 4T1 cells at 100 μM, which were comparable to that of camptothecin (81.61 %), and compound 7 (30 μM) exhibited a moderate inhibitory effect on NO release from LPS-induced BV2 cells, in addition to the moderate inhibitory effect of all compounds on the eeAChE.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.