Liliana Arriola-Montenegro , Maria Vera Sanchez , George Chen , Cana Brown , Megan Rasmussen , Carlysle Salter , Induja Gajendran , Benjamin Estrada
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引用次数: 0
Abstract
Background
Cardiovascular abnormalities may be caused by congenital or perinatal infections that cause cardiomyocyte injury and inflammation.
Aim of review
The purpose of this article is to review common congenital infections associated with cardiovascular sequelae, including pathogenesis, cardiovascular manifestations, diagnosis, treatment, prevention, and public health implications.
Key scientific concepts of review
Congenital rubella syndrome occurs from transplacental transmission of rubella virus and may cause patent ductus arteriosus, pulmonary valvular or pulmonary artery stenosis, or ventricular septal defect. Congenital HIV occurs from HIV transmission during pregnancy, delivery, or breastfeeding and may cause dilated cardiomyopathy, left ventricular dilation, thickening of the interventricular septum and posterior wall, or myocarditis. Enterovirus infection occurs from fecal-oral contact or respiratory transmission of enteroviruses such as coxsackievirus and may cause myocarditis and structural heart defects, especially ventricular septal defect. Zika virus infection occurs from mosquito bites, sexual contact, or transplacental transmission and may cause left ventricular hypertrophy, nondipping blood pressure, diastolic dysfunction, and valvular regurgitation. Other congenital viral infections that may cause cardiovascular disease include cytomegalovirus, parvovirus B19, and SARS-CoV-2.
Congenital syphilis occurs from transmission of Treponema pallidum during pregnancy or delivery and may cause aortitis, aortic aneurysm, and aortic regurgitation. Chagas disease occurs from Trypanosoma cruzi transmission through the feces of infected triatomine bugs, transplacental transmission, blood transfusions, and organ transplants and may cause arrhythmias, left ventricular wall motion abnormalities, complete heart block, ventricular dysfunction, and heart failure. Prevention of congenital infections may include vaccination, prenatal and perinatal screening, and other public health measures.
期刊介绍:
Progress in Pediatric Cardiology is an international journal of review presenting information and experienced opinion of importance in the understanding and management of cardiovascular diseases in children. Each issue is prepared by one or more Guest Editors and reviews a single subject, allowing for comprehensive presentations of complex, multifaceted or rapidly changing topics of clinical and investigative interest.