Effects of essential fatty acid deficiency on renal papillary lipid methylation.

IF 2.9 4区医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins, leukotrienes, and essential fatty acids Pub Date : 1988-09-01

R F O'Dea, T P Green, A R Sinaiko

引用次数: 0

Abstract

The relationship between lipid methylation and prostaglandin release was examined in rat renal papillae. Essential fatty acid deficiency (EFAD) was produced to deplete tissues of arachidonate precursors. The in vitro release of prostaglandin E was determined after exposure of the papillae to hypertonic sodium chloride. The EFAD animals were observed to have significantly less renal papillary lipid methylation than rats fed control diets (50%; P less than 0.05). However, stimulation of prostaglandin production in vitro was not accompanied by any detectable changes in total lipid methylation in tissues from either normal or EFAD rats.

本刊更多论文

必需脂肪酸缺乏对肾乳头状脂质甲基化的影响。

研究了大鼠肾乳头脂质甲基化与前列腺素释放的关系。必需脂肪酸缺乏症(EFAD)的产生是为了消耗组织中的花生四烯酸前体。高渗氯化钠对前列腺素E的体外释放量进行测定。EFAD动物的肾乳头状脂质甲基化明显低于饲喂对照饲料的大鼠(50%;P < 0.05)。然而，体外前列腺素生成的刺激并没有伴随着正常或EFAD大鼠组织中总脂质甲基化的任何可检测到的变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Prostaglandins, leukotrienes, and essential fatty acids 医学-内分泌学与代谢

CiteScore

6.40

自引率

6.70%

发文量

审稿时长

13.2 weeks

期刊介绍： The role of lipids, including essential fatty acids and their prostaglandin, leukotriene and other derivatives, is now evident in almost all areas of biomedical science. Cell membrane behaviour and cell signalling in all tissues are highly dependent on the lipid constituents of cells. Prostaglandins, Leukotrienes & Essential Fatty Acids aims to cover all aspects of the roles of lipids in cellular, organ and whole organism function, and places a particular emphasis on human studies. Papers concerning all medical specialties are published. Much of the material is particularly relevant to the development of novel treatments for disease.