Resting-state connectivity and task-based cortical response in post-stroke executive dysfunction: A fNIRS study

Q4 Neuroscience
Kayee Chong , Songmei Chen , Xixi Chen , Xiaolin Zhang , Deng Liu , Zhiqing Zhou , Xiaowen Wang , Jingjing Zhang , Chunlei Shan
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引用次数: 0

Abstract

Objective

This study attempted to investigate the frontoparietal cortical reorganization associated with executive function (EF) in post-stroke executive dysfunction (PSED) patients, focusing on resting-state, Stroop and 1-back task-based functional connectivity (FC) using functional near-infrared spectroscopy (fNIRS).

Methods

We recorded oxygenated hemoglobin concentration signals from bilateral inferior parietal lobule (R_IPL/L_IPL), pre-motor area (R_PMA/L_PMA), dorsolateral prefrontal cortex (R_DLPFC/L_DLPFC), Broca's area (R_Broca/L_Broca) and frontopolar cortex (FPC) of 20 PSED patients and 20 healthy controls (HCs). We compared group differences in cortical response, including functional connectivity (FC) during resting-state, task-based FC during Stroop and 1-back task as well as cortical activation during these tasks. Additionally, we analyzed the correlation between MoCA scores, task performance, and any specific cortical response that showed differences.

Results

PSED patients exhibited hypoactivation in executive-related regions during both Stroop and 1-back tasks compared to HCs. During the Stroop task, cross-hemispheric hyperconnectivity from the left inferior parietal lobule (IPL) to the right Broca's area suggested compensatory adaptation. During the 1-back task, within-frontal and intra-hemispheric hypoconnectivity indicated maladaptive neural reorganization. Correlation analyses revealed that increased directed FC from the left IPL to right Broca was positively associated with Stroop reaction time, while decreased directed FC from the right IPL to the frontopolar cortex (FPC) was negatively associated with 1-back task performance in PSED patients.

Conclusions

Our study highlights the importance of including the parietal cortex in fNIRS studies of PSED to obtain a comprehensive understanding of EF deficits. From the investigation of task-based cortical response, PSED patients exhibited different patterns of FC despite reduced task-based cortical activation: compensatory cross-hemispheric hyperconnectivity during the Stroop task, while maladaptive within-frontal and between IPL and frontopolar hypoconnectivity during the 1-back task. Incorporating the insights gained from our study, future research can explore multi-targeted neuromodulation strategies that address frontal and parietal cortices may be more effective in improving cognitive outcomes in stroke survivors.
脑卒中后执行功能障碍的静息状态连通性和基于任务的皮层反应:一项fNIRS研究
目的利用功能近红外光谱(fNIRS)研究脑卒中后执行功能障碍(PSED)患者与执行功能(EF)相关的额顶叶皮层重组,重点研究静息状态、Stroop和1-back任务型功能连接(FC)。方法记录20例PSED患者和20例健康对照(hc)的双侧下顶叶(R_IPL/L_IPL)、运动前区(R_PMA/L_PMA)、背外侧前额叶皮质(R_DLPFC/L_DLPFC)、布洛卡区(R_Broca/L_Broca)和额极皮质(FPC)的氧合血红蛋白浓度信号。我们比较了各组皮层反应的差异,包括静息状态下的功能连接(FC)、Stroop和1-back任务期间的任务型FC以及这些任务期间的皮层激活。此外,我们分析了MoCA分数、任务表现和任何表现出差异的特定皮层反应之间的相关性。结果与hc相比,spsed患者在Stroop和1-back任务中表现出执行相关区域的低激活。在Stroop任务中,从左侧顶叶下小叶(IPL)到右侧布洛卡区(Broca’s area)的跨半球超连通性表明代偿性适应。在1-back任务中,额内和半球内的低连通性表明神经重组不适应。相关性分析显示,从左IPL到右Broca的定向FC增加与Stroop反应时间呈正相关,而从右IPL到额极皮质(FPC)的定向FC减少与PSED患者的1-back任务表现呈负相关。结论我们的研究强调了将顶叶皮层纳入PSED的近红外光谱研究以全面了解EF缺陷的重要性。从任务型皮质反应的调查来看,PSED患者表现出不同的FC模式,尽管任务型皮质激活减少:Stroop任务期间代偿性跨半球超连通性,而1-back任务期间额内和IPL与额极之间的适应性不良。结合从我们的研究中获得的见解,未来的研究可以探索针对额叶和顶叶皮层的多目标神经调节策略,可能更有效地改善中风幸存者的认知结果。
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来源期刊
Neuroimage. Reports
Neuroimage. Reports Neuroscience (General)
CiteScore
1.90
自引率
0.00%
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0
审稿时长
87 days
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