Decoding N6-methyladenosine’s dynamic role in stem cell fate and early embryo development: insights into RNA–chromatin interactions

IF 3.7 2区生物学 Q2 CELL BIOLOGY

Current Opinion in Genetics & Development Pub Date : 2025-02-04 DOI:10.1016/j.gde.2025.102311

Lei Yang , Mingli Ma , Yawei Gao , Jun Liu

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引用次数: 0

Abstract

N⁶-methyladenosine (m⁶A), a reversible and dynamic RNA modification, plays pivotal roles in regulating stem cell pluripotency and early embryogenesis. Disruptions in m⁶A homeostasis lead to profound developmental defects, impairing processes such as stem cell self-renewal, lineage specification, oocyte maturation, zygotic genome activation, and maternal RNA degradation after fertilization. Beyond its well-recognized roles in mRNA transport, stability, and translation, recent studies have highlighted m⁶A’s critical role in transcriptional regulation through intricate RNA–chromatin interactions, notably involving chromatin-associated regulatory RNAs (carRNAs) and retrotransposon RNAs. This review delves into the dynamic regulatory landscape of m⁶A, highlighting its critical interplay with chromatin modifications, and explores its broader implications in stem cell biology and early embryonic development.

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解码n6 -甲基腺苷在干细胞命运和早期胚胎发育中的动态作用：rna -染色质相互作用的见解

n6 -甲基腺苷（n6 - methylladenosine, m6A）是一种可逆的、动态的RNA修饰，在干细胞多能性和早期胚胎发生调控中起着关键作用。m6A稳态的破坏会导致严重的发育缺陷，损害诸如干细胞自我更新、谱系规范、卵母细胞成熟、合子基因组激活和受精后母体RNA降解等过程。除了在mRNA转运、稳定性和翻译中众所周知的作用外，最近的研究强调了m6A通过复杂的rna -染色质相互作用在转录调控中的关键作用，特别是涉及染色质相关调控rna （carrna）和反转录转座子rna。这篇综述深入研究了m6A的动态调控格局，强调了它与染色质修饰的关键相互作用，并探讨了其在干细胞生物学和早期胚胎发育中的广泛意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Genetics & Development 生物-细胞生物学

CiteScore

7.90

自引率

0.00%

发文量

102

审稿时长

1 months

期刊介绍： Current Opinion in Genetics and Development aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Genetics and Development we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...] The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year: • Cancer Genomics • Genome Architecture and Expression • Molecular and genetic basis of disease • Developmental mechanisms, patterning and evolution • Cell reprogramming, regeneration and repair • Genetics of Human Origin / Evolutionary genetics (alternate years)