Two birds with one stone: A near-infrared AIE fluorescent probe for highly selective recognition of Cu2+/GSH and bioimaging

IF 4.1 3区化学 Q2 CHEMISTRY, PHYSICAL

Journal of Photochemistry and Photobiology A-chemistry Pub Date : 2025-01-03 DOI:10.1016/j.jphotochem.2025.116263

Yajie Dong , Rui Qiao , Qixiang Song , Mengyu Chen , Shizhen Wang , Jingde Hu , Xin Wang , Wenhui Xue , Yuanqian Zhang , Cuibing Bai , Changqing Qu , Hui Miao , Biao Wei

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Abstract

Although notable progress has been made in the identification of Cu²⁺ and glutathione (GSH), probes that can specifically recognize them simultaneously are still rare. Herein, we designed, synthesized, and characterized a fluorescent probe QA with aggregation-induced emission characteristics, a near-infrared emission wavelength (688 nm), a large Stokes shift (Δλ = 263 nm), and specific sequential recognition of Cu²⁺ and GSH. Compared with other probes, QA exhibits a fast fluorescence “ON-OFF” response to Cu²⁺, and its low limit of detection (LOD) toward Cu²⁺ is 3.53 × 10⁻⁸ M. Moreover, it can also detect Cu²⁺ in actual water samples. Moreover, QA-Cu²⁺ shows high sensitivity to GSH with an LOD of 3.47 × 10⁻⁷ M. Notably, the toxicity of QA is so low that it can recognize Cu²⁺ and GSH in various models, including HepG-2 cells, Caenorhabditis elegans, and adult mice, implying that it is a favorable applicant to detect Cu²⁺ and GSH in vitro and in vivo.

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来源期刊

Journal of Photochemistry and Photobiology A-chemistry 化学-物理化学

CiteScore

7.90

自引率

7.00%

发文量

580

审稿时长

48 days

期刊介绍： JPPA publishes the results of fundamental studies on all aspects of chemical phenomena induced by interactions between light and molecules/matter of all kinds. All systems capable of being described at the molecular or integrated multimolecular level are appropriate for the journal. This includes all molecular chemical species as well as biomolecular, supramolecular, polymer and other macromolecular systems, as well as solid state photochemistry. In addition, the journal publishes studies of semiconductor and other photoactive organic and inorganic materials, photocatalysis (organic, inorganic, supramolecular and superconductor). The scope includes condensed and gas phase photochemistry, as well as synchrotron radiation chemistry. A broad range of processes and techniques in photochemistry are covered such as light induced energy, electron and proton transfer; nonlinear photochemical behavior; mechanistic investigation of photochemical reactions and identification of the products of photochemical reactions; quantum yield determinations and measurements of rate constants for primary and secondary photochemical processes; steady-state and time-resolved emission, ultrafast spectroscopic methods, single molecule spectroscopy, time resolved X-ray diffraction, luminescence microscopy, and scattering spectroscopy applied to photochemistry. Papers in emerging and applied areas such as luminescent sensors, electroluminescence, solar energy conversion, atmospheric photochemistry, environmental remediation, and related photocatalytic chemistry are also welcome.