Non-Stoichiometric FeS2 nanoparticles as antibacterial agents with combined photothermal and photodynamic effect

IF 4.1 3区化学 Q2 CHEMISTRY, PHYSICAL

Journal of Photochemistry and Photobiology A-chemistry Pub Date : 2025-01-02 DOI:10.1016/j.jphotochem.2024.116260

Ahmed AlSarori , Abdurrahman Mustafa , Hasan Akyıldız , Ismail Cihan Kaya , Gulcihan Guzel Kaya

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Abstract

In this study, non-stoichiometric FeS₂ nanoparticles were synthesized via hot-injection method and evaluated as dual effect antibacterial agent. Non-stoichiometric FeS₂ nanoparticles were achieved by altering the molar ratio of the precursors (i.e., Fe-source and S-source). X-ray photoelectron spectroscopy (XPS) analysis revealed that Fe/S ratio in the FeS₂ nanoparticles were 1.012:2, 0.960:2, 0.905:2, and 0.900:2 for the samples with Fe-source to S-source ratios of 1/6, 1/8, 1/10, and 1/12, respectively. In the case of Fe/S: 0.900:2, the temperature increased up to about 53 °C (photothermal conversion efficiency: 52.6 %) in addition to reactive oxygen species (ROS) generation under 808 nm near-infrared (NIR) light irradiation. Based on the in vitro antibacterial activity tests, non-stoichiometric FeS₂ nanoparticles exhibited promising antibacterial activity against Escherichia coli (98.00%) and Staphylococcus aureus (99.89%) due to the synergistic effects of ROS formation and hyperthermia. The non-stoichiometric FeS₂ nanoparticles can be considered as high potential antibacterial material under NIR irradiation.

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来源期刊

Journal of Photochemistry and Photobiology A-chemistry 化学-物理化学

CiteScore

7.90

自引率

7.00%

发文量

580

审稿时长

48 days

期刊介绍： JPPA publishes the results of fundamental studies on all aspects of chemical phenomena induced by interactions between light and molecules/matter of all kinds. All systems capable of being described at the molecular or integrated multimolecular level are appropriate for the journal. This includes all molecular chemical species as well as biomolecular, supramolecular, polymer and other macromolecular systems, as well as solid state photochemistry. In addition, the journal publishes studies of semiconductor and other photoactive organic and inorganic materials, photocatalysis (organic, inorganic, supramolecular and superconductor). The scope includes condensed and gas phase photochemistry, as well as synchrotron radiation chemistry. A broad range of processes and techniques in photochemistry are covered such as light induced energy, electron and proton transfer; nonlinear photochemical behavior; mechanistic investigation of photochemical reactions and identification of the products of photochemical reactions; quantum yield determinations and measurements of rate constants for primary and secondary photochemical processes; steady-state and time-resolved emission, ultrafast spectroscopic methods, single molecule spectroscopy, time resolved X-ray diffraction, luminescence microscopy, and scattering spectroscopy applied to photochemistry. Papers in emerging and applied areas such as luminescent sensors, electroluminescence, solar energy conversion, atmospheric photochemistry, environmental remediation, and related photocatalytic chemistry are also welcome.