Multi-metal oxide/N-doped reduced graphene oxide modified electrode for ultrasensitive determination of phenobarbital

IF 5.4 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research Pub Date : 2025-02-01 DOI:10.1016/j.sbsr.2024.100720

Seyed Saman Nemati , Gholamreza Dehghan , Simin Khataee , Zohreh Shaghaghi

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引用次数: 0

Abstract

Phenobarbital (PB) is known for its sedative and anticonvulsant characteristics, making it a critical agent for the management of epilepsy and seizure disorders. Considering its narrow therapeutical range, accurate monitoring of this drug is highly recommended to prevent side effects. Herein, we successfully introduced trimetallic graphene oxide-based nanocomposite consisting of cerium oxide, nickel oxide, and copper oxide (III@N-rGO), which benefits the synergistic properties of each compound for electrochemical sensing applications. The structure of the nanostructures was evaluated using Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction pattern (XRD), Raman spectroscopy, field emission scanning electron microscope images (FE-SEM), and transmission electron microscope (TEM). Various electrochemical techniques were employed to investigate the sensor's electrocatalytic performance, following the carbon paste electrode's construction. The target electrode represented superior sensing efficiency, including a broad linear range of 0.1–840 μM, proper sensitivity of 1.389 ± 0.013 mA μM⁻¹ cm⁻², low detection limit of 9.10 ± 0.002 nM at the optimum potential of 0.72 V. Furthermore, III@N-rGO electrode illustrated good long-term stability, good reproducibility, and excellent selectivity. The results of recovery tests in human serum and pharmaceutical samples (94–106 %) with desired RSD values (below 3 %) demonstrated the practical applicability of the case-studied sensor. Hence, the proposed platform has the potential to serve as a promising model for PB detection.

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来源期刊

Sensing and Bio-Sensing Research Engineering-Electrical and Electronic Engineering

CiteScore

10.70

自引率

3.80%

发文量

审稿时长

87 days

期刊介绍： Sensing and Bio-Sensing Research is an open access journal dedicated to the research, design, development, and application of bio-sensing and sensing technologies. The editors will accept research papers, reviews, field trials, and validation studies that are of significant relevance. These submissions should describe new concepts, enhance understanding of the field, or offer insights into the practical application, manufacturing, and commercialization of bio-sensing and sensing technologies. The journal covers a wide range of topics, including sensing principles and mechanisms, new materials development for transducers and recognition components, fabrication technology, and various types of sensors such as optical, electrochemical, mass-sensitive, gas, biosensors, and more. It also includes environmental, process control, and biomedical applications, signal processing, chemometrics, optoelectronic, mechanical, thermal, and magnetic sensors, as well as interface electronics. Additionally, it covers sensor systems and applications, µTAS (Micro Total Analysis Systems), development of solid-state devices for transducing physical signals, and analytical devices incorporating biological materials.