Enhanced clinical photoacoustic vascular imaging through a skin localization network and adaptive weighting

IF 7.1 1区医学 Q1 ENGINEERING, BIOMEDICAL

Photoacoustics Pub Date : 2025-01-21 DOI:10.1016/j.pacs.2025.100690

Chuqin Huang , Emily Zheng , Wenhan Zheng , Huijuan Zhang , Yanda Cheng , Xiaoyu Zhang , Varun Shijo , Robert W. Bing , Isabel Komornicki , Linda M. Harris , Ermelinda Bonaccio , Kazuaki Takabe , Emma Zhang , Wenyao Xu , Jun Xia

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引用次数: 0

Abstract

Photoacoustic tomography (PAT) is an emerging imaging modality with widespread applications in both preclinical and clinical studies. Despite its promising capabilities to provide high-resolution images, the visualization of vessels might be hampered by skin signals and attenuation in tissues. In this study, we have introduced a framework to retrieve deep vessels. It combines a deep learning network to segment skin layers and an adaptive weighting algorithm to compensate for attenuation. Evaluation of enhancement using vessel occupancy metrics and signal-to-noise ratio (SNR) demonstrates that the proposed method significantly recovers deep vessels across various body positions and skin tones. These findings indicate the method’s potential to enhance quantitative analysis in preclinical and clinical photoacoustic research.

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来源期刊

Photoacoustics Physics and Astronomy-Atomic and Molecular Physics, and Optics

CiteScore

11.40

自引率

16.50%

发文量

审稿时长

53 days

期刊介绍： The open access Photoacoustics journal (PACS) aims to publish original research and review contributions in the field of photoacoustics-optoacoustics-thermoacoustics. This field utilizes acoustical and ultrasonic phenomena excited by electromagnetic radiation for the detection, visualization, and characterization of various materials and biological tissues, including living organisms. Recent advancements in laser technologies, ultrasound detection approaches, inverse theory, and fast reconstruction algorithms have greatly supported the rapid progress in this field. The unique contrast provided by molecular absorption in photoacoustic-optoacoustic-thermoacoustic methods has allowed for addressing unmet biological and medical needs such as pre-clinical research, clinical imaging of vasculature, tissue and disease physiology, drug efficacy, surgery guidance, and therapy monitoring. Applications of this field encompass a wide range of medical imaging and sensing applications, including cancer, vascular diseases, brain neurophysiology, ophthalmology, and diabetes. Moreover, photoacoustics-optoacoustics-thermoacoustics is a multidisciplinary field, with contributions from chemistry and nanotechnology, where novel materials such as biodegradable nanoparticles, organic dyes, targeted agents, theranostic probes, and genetically expressed markers are being actively developed. These advanced materials have significantly improved the signal-to-noise ratio and tissue contrast in photoacoustic methods.