Validating the SONG-PKD Pain Instrument, a Core Outcome Measure for Pain in ADPKD

IF 5.7 2区医学 Q1 UROLOGY & NEPHROLOGY

Kidney International Reports Pub Date : 2025-02-01 DOI:10.1016/j.ekir.2024.11.015

Rosanna Cazzolli , Angela Ju , Patrizia Natale , Armando Teixeira-Pinto , Martin Howell , Allison Jaure , Ronald D. Perrone , Eva Burnette , Niek F. Casteleijn , Arlene Chapman , Jonathan C. Craig , Sarah Eastty , Ron T. Gansevoort , Tess Harris , Marie C. Hogan , Shigeo Horie , Bertrand Knebelmann , Richard Lee , Karine Manera , Reem A. Mustafa , Yeoungjee Cho

{"title":"Validating the SONG-PKD Pain Instrument, a Core Outcome Measure for Pain in ADPKD","authors":"Rosanna Cazzolli , Angela Ju , Patrizia Natale , Armando Teixeira-Pinto , Martin Howell , Allison Jaure , Ronald D. Perrone , Eva Burnette , Niek F. Casteleijn , Arlene Chapman , Jonathan C. Craig , Sarah Eastty , Ron T. Gansevoort , Tess Harris , Marie C. Hogan , Shigeo Horie , Bertrand Knebelmann , Richard Lee , Karine Manera , Reem A. Mustafa , Yeoungjee Cho","doi":"10.1016/j.ekir.2024.11.015","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>Pain is a critically important outcome in autosomal dominant polycystic kidney disease (ADPKD); however, it is infrequently and inconsistently reported in clinical trials. This study aimed to validate the Standardized Outcomes in Nephrology-Polycystic Kidney Disease (SONG-PKD) Pain measure, which includes 3 items related to pain (frequency, severity, and impact on life participation) measured on a 5-point Likert scale, in adults with ADPKD.</div></div><div><h3>Methods</h3><div>A total of 316 adults with ADPKD from 21 countries participated online. The median (interquartile range) age of participants was 56 (44–66) years, 219 (69%) were female, and 222 (70%) had a university degree or higher. Participants completed a demographic questionnaire, brief medical history, and 4 pain measures at baseline. The pain measures were readministered 2 days later. Internal consistency was evaluated with Cronbach’s alpha. Test-retest reliability was assessed using intraclass correlation coefficient (ICC), and convergent validity was assessed using Spearman’s rho. Known groups comparisons for patients with or without a history of kidney complications were performed using a Mann-Whitney rank sum test.</div></div><div><h3>Results</h3><div>The SONG-PKD Pain measure demonstrated high internal consistency (0.94, 95% confidence interval [CI]: 0.93–0.95) and test-retest reliability (0.92, 95% CI: 0.90–0.94). There was a high convergence of SONG-PKD Pain with the Brief Pain Inventory-Short Form (BPI-SF; 0.84, 95% CI: 0.80–0.87) and a visual analog scale (VAS; 0.84, 95% CI: 0.81–0.87). There was a significant difference in the median scores of patients with and without a history of complications (4.0 vs. 0.0, <em>P</em> < 0.001).</div></div><div><h3>Conclusion</h3><div>SONG-PKD Pain instrument is a brief and simple measure that has demonstrated strong psychometric properties.</div></div>","PeriodicalId":17761,"journal":{"name":"Kidney International Reports","volume":"10 2","pages":"Pages 447-456"},"PeriodicalIF":5.7000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Kidney International Reports","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468024924020369","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction

Pain is a critically important outcome in autosomal dominant polycystic kidney disease (ADPKD); however, it is infrequently and inconsistently reported in clinical trials. This study aimed to validate the Standardized Outcomes in Nephrology-Polycystic Kidney Disease (SONG-PKD) Pain measure, which includes 3 items related to pain (frequency, severity, and impact on life participation) measured on a 5-point Likert scale, in adults with ADPKD.

Methods

A total of 316 adults with ADPKD from 21 countries participated online. The median (interquartile range) age of participants was 56 (44–66) years, 219 (69%) were female, and 222 (70%) had a university degree or higher. Participants completed a demographic questionnaire, brief medical history, and 4 pain measures at baseline. The pain measures were readministered 2 days later. Internal consistency was evaluated with Cronbach’s alpha. Test-retest reliability was assessed using intraclass correlation coefficient (ICC), and convergent validity was assessed using Spearman’s rho. Known groups comparisons for patients with or without a history of kidney complications were performed using a Mann-Whitney rank sum test.

Results

The SONG-PKD Pain measure demonstrated high internal consistency (0.94, 95% confidence interval [CI]: 0.93–0.95) and test-retest reliability (0.92, 95% CI: 0.90–0.94). There was a high convergence of SONG-PKD Pain with the Brief Pain Inventory-Short Form (BPI-SF; 0.84, 95% CI: 0.80–0.87) and a visual analog scale (VAS; 0.84, 95% CI: 0.81–0.87). There was a significant difference in the median scores of patients with and without a history of complications (4.0 vs. 0.0, P < 0.001).

Conclusion

SONG-PKD Pain instrument is a brief and simple measure that has demonstrated strong psychometric properties.

Abstract Image

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Kidney International Reports Medicine-Nephrology

CiteScore

7.70

自引率

3.30%

发文量

1578

审稿时长

8 weeks

期刊介绍： Kidney International Reports, an official journal of the International Society of Nephrology, is a peer-reviewed, open access journal devoted to the publication of leading research and developments related to kidney disease. With the primary aim of contributing to improved care of patients with kidney disease, the journal will publish original clinical and select translational articles and educational content related to the pathogenesis, evaluation and management of acute and chronic kidney disease, end stage renal disease (including transplantation), acid-base, fluid and electrolyte disturbances and hypertension. Of particular interest are submissions related to clinical trials, epidemiology, systematic reviews (including meta-analyses) and outcomes research. The journal will also provide a platform for wider dissemination of national and regional guidelines as well as consensus meeting reports.