Intestinal colonisation of vancomycin-resistant enterococci among patients with cancer at Jimma University Medical Center, Ethiopia: A comparative cross-sectional study

IF 3.7 3区医学 Q2 INFECTIOUS DISEASES

Journal of global antimicrobial resistance Pub Date : 2024-12-25 DOI:10.1016/j.jgar.2024.12.025

Amanuel Teferi , Rahel Tamrat , Diriba Fufa , Kasahun Gorems , Tadele Akeba Diriba , Mulualem Tadesse

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引用次数: 0

Abstract

Objective

Vancomycin-resistant enterococci (VRE) pose a major threat in hospital settings. Patients with cancer are at a higher risk of hospital-acquired infections such as VRE. This study aimed to determine the intestinal colonisation rate of VRE in patients with cancer at Jimma University Medical Center, southwest Ethiopia.

Methods

A comparative cross-sectional study was conducted prospectively from April to September 2021 at Jimma University Medical Center on 113 patients with cancer. An equal number of apparently healthy individuals were included for comparison. Stool samples were collected from both patients with cancer and apparently healthy individuals, then cultured on bile esculin azide agar. Vancomycin resistance was determined by minimum inhibitory concentration and disk diffusion method, whereas antibiotic susceptibility to other antibiotics was performed by disk diffusion method. Data were entered into Epidata v. 4.6.0.6 and analysed by SPSS v. 26.

Results

The overall colonisation rate of Enterococcus species was 76.9% (87/113) in patients with cancer and 80.5% (91/113) in apparently healthy individuals, with no statistically significant difference. However, the intestinal colonisation rate of VRE was higher in patients with cancer (12.6%; 11/87) compared with apparently healthy individuals (4.4%, 4/91). VRE isolates showed the highest resistance to tetracycline (66.7%) and the lowest resistance to chloramphenicol (13.3%). Multidrug resistance was observed in more than half (66.7%; 10/15) of the VRE isolates.

Conclusions

The intestinal colonisation rate by VRE was higher in patients with cancer compared with healthy individuals. Regular screening for VRE colonisation, along with improved infection-prevention practices, are vital to reduce the risk of VRE infections.

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来源期刊

Journal of global antimicrobial resistance INFECTIOUS DISEASES-PHARMACOLOGY & PHARMACY

CiteScore

8.70

自引率

2.20%

发文量

285

审稿时长

34 weeks

期刊介绍： The Journal of Global Antimicrobial Resistance (JGAR) is a quarterly online journal run by an international Editorial Board that focuses on the global spread of antibiotic-resistant microbes. JGAR is a dedicated journal for all professionals working in research, health care, the environment and animal infection control, aiming to track the resistance threat worldwide and provides a single voice devoted to antimicrobial resistance (AMR). Featuring peer-reviewed and up to date research articles, reviews, short notes and hot topics JGAR covers the key topics related to antibacterial, antiviral, antifungal and antiparasitic resistance.