Flap endonuclease 1 (FEN1) biomarker as a new diagnostic target for the biosensing of cancer

IF 6.5 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Sensors and Actuators Reports Pub Date : 2024-12-09 DOI:10.1016/j.snr.2024.100270

Saba Mahboubi , Mehdi Evazalipour , Ehsan Zamani , Nozhat Zebardast , Alireza Farokhrouz , Rahim Nosrati

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引用次数: 0

Abstract

Flap endonuclease 1 (FEN1) is a structure-specific nuclease that plays a role in DNA replication and genome stability. FEN1 is overexpressed in proliferative cancers and correlates with the grade and aggressiveness of the cancer, suggesting that it could potentially be considered a promising biomarker for various cancer types. Due to the initiation of cancer is related to the lack of the activity of FEN1 nuclease, the detection and quantification of FEN1 is significance for cancer diagnosis in early stage. There are various approaches to detect the different types of cancer biomarkers. In this context, biosensing platforms and nanotechnology-based methods have attracted much attention. To date, the sensitivity and performance of biosensors can enhance by nanomaterials/nanoparticles that have been incorporated in biosensing platforms. This review overview a brief classification and description of the advancement of biosensors and nanobiosensors for the detection and quantitation of FEN1 based on optical and electrochemical platforms.

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来源期刊

Sensors and Actuators Reports Multiple-

CiteScore

9.60

自引率

0.00%

发文量

审稿时长

49 days

期刊介绍： Sensors and Actuators Reports is a peer-reviewed open access journal launched out from the Sensors and Actuators journal family. Sensors and Actuators Reports is dedicated to publishing new and original works in the field of all type of sensors and actuators, including bio-, chemical-, physical-, and nano- sensors and actuators, which demonstrates significant progress beyond the current state of the art. The journal regularly publishes original research papers, reviews, and short communications. For research papers and short communications, the journal aims to publish the new and original work supported by experimental results and as such purely theoretical works are not accepted.