Determination of chemical composition, antimicrobial activity and in silico investigation of the essential oil extracted from peels of Citrus medica (Jora Tenga) & Citrus jambhiri (Gol Nemu) grown in north eastern region of India

Pharmacological Research - Natural Products Pub Date : 2025-01-02 DOI:10.1016/j.prenap.2024.100139

Rashmita Gogoi , Siddhartha Sankar Das , Simi Deka , Abhijita Talukder , Bhargab Jyoti Sahariah , Tarun Kumar Dua , Koushik Nandan Dutta

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Abstract

Citrus medica and Citrus jambhiri locally known as ''Jora tenga,' and ‘Gul nemu' in Assam, which has been traditionally used in the region for its medicinal properties and is highly regarded for their therapeutic benefits in local remedies. Our aim in this study to explore the chemical composition of the essential oil isolated from C. medica and C. jambhiri peel and determine their in vitro and in silico antimicrobial activity. GCMS study of the oils extracted from C. medica and C. jambhiri fruits yielded a total of 177 and 227 compounds, respectively. The common chemicals are found from both the lemon peel oil are D-Limonene, α -Pinene, Geraniol, β -Bisabolene, α -Bisabolol, Linalool, and Caryophyllene. In silico study showed that these compounds should be responsible for antibacterial activity, which are most abundant in oil. C. medica and C. jambhiri peel oil also showed promising antibacterial activity against gram positive bacteria Enterococcus faecalis and gram negative bacteria Escherichia coli.

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Pharmacological Research - Natural Products

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