Charge-specific and hesperidin loaded mesoporous silica nanoparticles: Enhanced antimicrobial activity against pathogenic bacteria

IF 5.45 Q1 Physics and Astronomy

Nano-Structures & Nano-Objects Pub Date : 2025-02-01 DOI:10.1016/j.nanoso.2025.101441

Divya Sree H.R., Satyanarayana Swamy Vyshnava, Muralidhara Rao Dowlathabad

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引用次数: 0

Abstract

This study successfully synthesized and evaluated mesoporous silica nanoparticles (MSNs) for charge-based antimicrobial delivery systems. The presence and development of MSN particles were verified by UV-Visible spectroscopy, which exhibited distinct peaks that corresponded with prior research. The MSNs, which were examined using HR-TEM (high-resolution transmission electron microscopy) and FE-SEM (field emission scanning electron microscopy), had a spherical shape with an average diameter of 65.0 ± 2.0 nm. They were found to be amorphous, as confirmed by XRD (X-ray diffraction) and SAED (selected area electron diffraction) patterns. The presence of amino, carboxyl, and PEG groups on the surface was confirmed by FTIR, suggesting that the modification was successful. The modified MSNs exhibited differences in hydrodynamic size and surface charge, as evidenced by dynamic light scattering (DLS) and zeta potential tests. The most efficient loading of hesperidin (Hes) was attained when the ratio of MSN to Hes was 1:10, as determined by UV-Visible spectra. The MSN-Hesperidin with a positive charge displayed the most potent antibacterial action against E. coli and Pseudomonas aeruginosa. It showed greater effectiveness compared to MSNs with a negative charge, MSNs with no charge, and free Hesperidin. The improved antibacterial efficacy can be ascribed to the efficient interaction between positively charged MSNs and bacterial cell membranes, along with the regulated release characteristics of the MSNs.

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来源期刊

Nano-Structures & Nano-Objects Physics and Astronomy-Condensed Matter Physics

CiteScore

9.20

自引率

0.00%

发文量

审稿时长

22 days

期刊介绍： Nano-Structures & Nano-Objects is a new journal devoted to all aspects of the synthesis and the properties of this new flourishing domain. The journal is devoted to novel architectures at the nano-level with an emphasis on new synthesis and characterization methods. The journal is focused on the objects rather than on their applications. However, the research for new applications of original nano-structures & nano-objects in various fields such as nano-electronics, energy conversion, catalysis, drug delivery and nano-medicine is also welcome. The scope of Nano-Structures & Nano-Objects involves: -Metal and alloy nanoparticles with complex nanostructures such as shape control, core-shell and dumbells -Oxide nanoparticles and nanostructures, with complex oxide/metal, oxide/surface and oxide /organic interfaces -Inorganic semi-conducting nanoparticles (quantum dots) with an emphasis on new phases, structures, shapes and complexity -Nanostructures involving molecular inorganic species such as nanoparticles of coordination compounds, molecular magnets, spin transition nanoparticles etc. or organic nano-objects, in particular for molecular electronics -Nanostructured materials such as nano-MOFs and nano-zeolites -Hetero-junctions between molecules and nano-objects, between different nano-objects & nanostructures or between nano-objects & nanostructures and surfaces -Methods of characterization specific of the nano size or adapted for the nano size such as X-ray and neutron scattering, light scattering, NMR, Raman, Plasmonics, near field microscopies, various TEM and SEM techniques, magnetic studies, etc .