{"title":"Anticancer potential of different phytoconstituents against breast cancer: Is the hope for the new drug discovery","authors":"Akash Vikal , Rashmi Maurya , Satyam Khare , Saurabh Bhargava , Preeti Patel , Ghanshyam Das Gupta , Balak Das Kurmi","doi":"10.1016/j.prenap.2024.100133","DOIUrl":null,"url":null,"abstract":"<div><div>This review explores the potential of phytoconstituents derived from plants as a novel and effective strategy for treating breast cancer, a prevalent and life-threatening condition affecting women worldwide. The study conducted a systematic review of the literature, analyzing data from diverse studies, including <em>in vitro</em> and <em>in vivo</em> experiments as well as clinical trials. The search focused on natural compounds' impact on breast cancer cells, emphasizing mechanisms such as apoptosis induction, hormonal signaling regulation, and overcoming drug resistance while minimizing adverse effects. The findings reveal a myriad of natural compounds demonstrating anticancer potential in breast cancer cells. These compounds, sourced from plants, exhibit the ability to target multiple pathways, offering a multi-faceted approach to breast cancer treatment. Notably, many of these compounds show minimal adverse effects, indicating their potential for clinical application. The study underscores the promise of phytoconstituents in enhancing survival rates and improving the quality of life for individuals with breast cancer. This review not only consolidates existing knowledge but also paves the way for future investigations into these biological agents, offering hope for a new era in breast cancer treatment and inspiring optimism among patients and clinicians alike.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"6 ","pages":"Article 100133"},"PeriodicalIF":0.0000,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacological Research - Natural Products","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2950199724001216","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
This review explores the potential of phytoconstituents derived from plants as a novel and effective strategy for treating breast cancer, a prevalent and life-threatening condition affecting women worldwide. The study conducted a systematic review of the literature, analyzing data from diverse studies, including in vitro and in vivo experiments as well as clinical trials. The search focused on natural compounds' impact on breast cancer cells, emphasizing mechanisms such as apoptosis induction, hormonal signaling regulation, and overcoming drug resistance while minimizing adverse effects. The findings reveal a myriad of natural compounds demonstrating anticancer potential in breast cancer cells. These compounds, sourced from plants, exhibit the ability to target multiple pathways, offering a multi-faceted approach to breast cancer treatment. Notably, many of these compounds show minimal adverse effects, indicating their potential for clinical application. The study underscores the promise of phytoconstituents in enhancing survival rates and improving the quality of life for individuals with breast cancer. This review not only consolidates existing knowledge but also paves the way for future investigations into these biological agents, offering hope for a new era in breast cancer treatment and inspiring optimism among patients and clinicians alike.