Synthesis of hyper-crosslinked porous polymers for drug release

IF 4.8 3区材料科学 Q1 CHEMISTRY, APPLIED

Microporous and Mesoporous Materials Pub Date : 2024-12-28 DOI:10.1016/j.micromeso.2024.113484

Rui Gao, Mengxin Li, Yuanxue Li

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Abstract

This study aimed to synthesize drug-loaded hyper-crosslinked porous polymers (HCPs) under high-temperature, anhydrous, oxygen-free conditions through a Friedel–Crafts reaction. The resulting hyper-crosslinked porous polymers were characterized by infrared spectroscopy, nitrogen adsorption porosity measurements, thermo-gravimetric analysis, field-emission scanning electron microscopy, and powder X-ray diffraction for HCPs, and the electrochemical properties were investigated. The specific surface areas of the hyper-crosslinked porous polymers reached as high as 1079 m²g⁻¹. We next investigated the use of one of the HCP samples as a drug delivery system and demonstrated its ability to release the model drug ibuprofen. Under selected synthesis conditions, the loading efficiency of the HCP with ibuprofen was 35 % (w/w). The release of the drug was also monitored, and 88 % of the loaded drug was released within 12 h. The resulting hyper-crosslinked porous polymer can be used as a matrix for the in vitro loading of ibuprofen.

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来源期刊

Microporous and Mesoporous Materials 化学-材料科学：综合

CiteScore

10.70

自引率

5.80%

发文量

649

审稿时长

26 days

期刊介绍： Microporous and Mesoporous Materials covers novel and significant aspects of porous solids classified as either microporous (pore size up to 2 nm) or mesoporous (pore size 2 to 50 nm). The porosity should have a specific impact on the material properties or application. Typical examples are zeolites and zeolite-like materials, pillared materials, clathrasils and clathrates, carbon molecular sieves, ordered mesoporous materials, organic/inorganic porous hybrid materials, or porous metal oxides. Both natural and synthetic porous materials are within the scope of the journal. Topics which are particularly of interest include: All aspects of natural microporous and mesoporous solids The synthesis of crystalline or amorphous porous materials The physico-chemical characterization of microporous and mesoporous solids, especially spectroscopic and microscopic The modification of microporous and mesoporous solids, for example by ion exchange or solid-state reactions All topics related to diffusion of mobile species in the pores of microporous and mesoporous materials Adsorption (and other separation techniques) using microporous or mesoporous adsorbents Catalysis by microporous and mesoporous materials Host/guest interactions Theoretical chemistry and modelling of host/guest interactions All topics related to the application of microporous and mesoporous materials in industrial catalysis, separation technology, environmental protection, electrochemistry, membranes, sensors, optical devices, etc.

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