A case of opsoclonus-myoclonus syndrome associated with breast cancer

Abstract

Opsoclonus-myoclonus syndrome (OMS) is a rare presenting complication of cancer that is thought to be related to autoimmune mediated perturbation of homeostasis of oculomotor and limb movement. Symptoms can include arrhythmic conjugate saccades of the eyes without interval and involuntary movements of the limbs. The patient was a 56-year-old woman with OMS and an occult axillary cT0N1M0 triple negative breast cancer (TNBC). She had negative serum and CSF serology. She was initially treated with steroids and immune globulin and then neoadjuvant chemotherapy. She underwent surgical excision and radiation. At 9 years the patient is without recurrence of OMS or TNBC.