Design, synthesis of N-thianyl indole acetamide derivatives as potential plant growth regulator

Abstract

The design, synthesis, and testing of acetamide derivatives containing indole structures (C) were carried out to determine their potential for regulating plant growth. The root growth of Arabidopsis thaliana was strongly inhibited by certain compounds, with compounds C2, C4, C6, and C7 achieving a 100 % inhibitory rate at a concentration of 100 µM. The growth of lateral roots in A. thaliana was significantly promoted by compounds C2 and C6 at a concentration of 50 µM. Additionally, these compounds have been found to increase the expression of genes associated with lateral root development, including IAA14, LAX3, AXR3, GH3.1, GH3.3, and BRU6. These genes are involved in the auxin signaling pathway and IAA-amino synthase-related genes. In brief, these target compounds may be promising lead compounds for developing agents that can regulate plant growth.