Effects of Puping Qinghua in the management of patients infected with SARS-CoV-2: a prospective, randomised, case-control study

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine Pub Date : 2025-02-01 DOI:10.1016/j.hermed.2024.100977

Chenyang Liu , Bin Chen , Youhua Wang , Wei Zhai , Qixiang Song , Hai Li , Lei Qiu , Duan Zhou , Yingen Wu , Min Cao

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引用次数: 0

Abstract

Background

Traditional Chinese medicine (TCM) has demonstrated considerable clinical efficacy in treating coronavirus disease 2019 (COVID-19). Puping Qinghua prescription (PPQH), a traditional Chinese medicine formulation, was found to be effective against clinical symptoms in patients with Omicron variant virus infection, Nonetheless, its safety and mechanism are unclear.

Purpose

To provide evidence of validity and adverse events associated with PPQH in treating SARS-CoV-2 Omicron variants infection.

Methods

Four hundred and eighty patients diagnosed with COVID-19 were randomised into the PPQH group (n = 240) and the LLQW group (n = 240). Basic information such as age, sex, vaccination status, symptoms, etc were registered. Laboratory tests for 142 patients, including cytokine levels and lymphocyte counts, liver and kidney function.

Results

After intervention, levels of NK cells, IFN-α, IL-5, IL-6, and IL-12p70 were reduced in the PPQH group, whereas the levels of TNF-α, IL-1β, IL-4, IL-6, and IL-17A were reduced in the Lianhua Qingwen (LHQW) group (P < 0.05). PPQH was more effective in shortening duration of fever and reducing degree of cough compared with LHQW (P < 0.05). Liver and kidney functions remained unimpaired before and after intervention in both groups (P > 0.05). In addition, the incidence of adverse reactions such as palpitations, dizziness and sweating was lower in the PPQH group (P < 0.05).

Conclusion

The efficacy of PPQH is comparable to LHQW in patients infected with Omicron variant virus. More excitingly, PPQH demonstrates a higher level of security.

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来源期刊

Journal of Herbal Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

3.90

自引率

0.00%

发文量

期刊介绍： The Journal of Herbal Medicine, the official journal of the National Institute of Medical Herbalists, is a peer reviewed journal which aims to serve its readers as an authoritative resource on the profession and practice of herbal medicine. The content areas of the journal reflect the interests of Medical Herbalists and other health professionals interested in the clinical and professional application of botanical medicines. The objective is to strengthen the research and educational base of herbal medicine with research papers in the form of case studies, original research articles and reviews, monographs, clinical trials and relevant in vitro studies. It also publishes policy statements, opinion pieces, book reviews, conference proceedings and profession related information such as pharmacovigilance reports providing an information source for not only the Herbal Practitioner but any Health professional with an interest in phytotherapy.