Neural correlates of reduction in self-judgment after mindful self-compassion training: A pilot study with resting state fMRI

Abstract

Self-judgment is a trans-diagnostic symptom among various psychological disorders, therefore can be a therapeutic target for many common psychiatric conditions. Self-judgment often arises among those who experienced childhood maltreatment, which increases the risk for developing comorbid psychiatric disorders that are resistant to traditional pharmacological and psychological interventions. Understanding the neural correlates of the therapeutic effect of behavioral interventions for reducing self-judgment is key for developing and refining evidence-based intervention programs. This single arm pilot study (N = 24) explored the neural correlates of reduction in self-judgment after an eight-week mindful self-compassion (MSC) intervention program for a sample of adult patients with either anxiety or depressive disorders, with 83 % having more than one diagnoses. The results demonstrated significant reduction of self-judgment after the intervention (p < 0.001, d = −1.04) along with increased self-compassion (p < 0.001, d =1.20); in particular, participants with above median score on the Childhood Trauma Questionnaire had significantly more improvement than those with below median scores (p < 0.05). Resting state fMRI was used to study neural correlates and showed that reduced self-judgment was associated with increased posterior cingulate cortex functional connectivity with dorsal lateral prefrontal cortex, inferior frontal gyrus, and dorsal medial prefrontal cortex, accompanied by reduced posterior cingulate cortex functional connectivity with the amygdala-hippocampal complex. These findings suggest reduced self-judgment after MSC training was substantiated by reduced fear circuitry influences on self-referential processes along with enhanced frontal regulation from the executive network and language network.