Uveitis in spondyloarthritis patients: Relation to clinical characteristics

IF 1 Q4 RHEUMATOLOGY

Egyptian Rheumatologist Pub Date : 2025-01-15 DOI:10.1016/j.ejr.2025.01.001

Hanan M. Farouk , Amina B. Abdelaziz , Mohammad A. Rashad , Nashwa A. Morshedy , Madonna H. Gad , Dalia A. ElSherbiny

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Abstract

Aim of the work

To assess the prevalence of uveitis in SpA patients and determine its association with clinical manifestations, laboratorial, radiological, and therapeutic data.

Patients and methods

This work included 81 adult SpA patients. Detailed medical history was taken. Full clinical and ophthalmological examinations were performed.

Results

The mean age of patients was 37.4 ± 9.3 years, 51 males and 30 females with positive family history of SpA in 18.5 %. 22 (27.2 %) had uveitis which was anterior in 18 (81.8 %), posterior in 5 (22.7 %), acute in 15 (68.2 %), unilateral in 15 (68.2 %). Regarding ophthalmology examination, 3 (3.7 %) had cataract, 1 (1.2 %) had glaucoma, 1 (1.2 %) had visual loss and 2 (2.5 %) had ocular surgery. In univariate analysis, there was significant association between uveitis and age, family history, erythrocyte sedimentation rate (ESR) > 28 mm/1^sthr, C-reactive protein (CRP) > 11 mg/dl, hemoglobin ≤ 11.2 g/dl, white blood cell count (WBCs) > 7.5 ×10³/mm³, platelets > 345 ×10³/mm³, human leucocytic antigen (HLA-B27) and sacroiliitis. In multivariate analysis, there was significant association between uveitis and age (p = 0.061), ESR > 28 mm/1^sthr (p = 0.023), CRP > 11 mg/dl (p = 0.018), hemoglobin ≤ 11.2 g/dl (p = 0.015), platelets > 345 ×10³/mm³ (p = 0.059) and sacroiliitis (p = 0.024).

Conclusion

Uveitis in patients with SpA is common especially with increase in age. With a positive family history of SpA and/or long disease duration, occurrence of uveitis should not be neglected. Uveitis is related also to inflammatory markers, HLA-B27 and sacroiliitis. Routine screening for uveitis in SpA patients is crucial for better early disease management.

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颈椎病患者葡萄膜炎：与临床特征的关系

研究目的评估SpA患者葡萄膜炎的患病率，并确定其与临床表现、实验室、放射学和治疗数据的关系。患者与方法本研究纳入81例成人SpA患者。记录了详细的病史。进行了全面的临床和眼科检查。结果患者平均年龄37.4±9.3岁，男性51例，女性30例，家族史阳性占18.5%。22例（27.2%）有葡萄膜炎，其中前型18例（81.8%），后型5例（22.7%），急性型15例（68.2%），单侧15例（68.2%）。眼科检查中，白内障3例（3.7%），青光眼1例（1.2%），视力下降1例（1.2%），眼部手术2例（2.5%）。在单因素分析中，葡萄膜炎与年龄、家族史、红细胞沉降率（ESR）和gt有显著相关；28mm / 1thr， c反应蛋白（CRP） >；11 mg/dl，血红蛋白≤11.2 g/dl，白细胞计数（WBCs） >；7.5 ×103/mm3，血小板；345 ×103/mm3，人白细胞抗原（HLA-B27）和骶髂炎。在多因素分析中，葡萄膜炎与年龄有显著相关性（p = 0.061）， ESR >；28 mm/ 1thr (p = 0.023), CRP >；11 mg / dl (p = 0.018),血红蛋白≤11.2 g / dl (p = 0.015),血小板比;345 ×103/mm3 （p = 0.059）和骶髂炎（p = 0.024）。结论葡萄膜炎在SpA患者中较为常见，且随年龄的增长而增加。有SpA阳性家族史和/或病程长，不应忽视葡萄膜炎的发生。葡萄膜炎也与炎症标志物、HLA-B27和骶髂炎有关。SpA患者的葡萄膜炎常规筛查对于更好的早期疾病管理至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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