Evaluate the enantioselective behavior of ethiprole: Implications for aquatic systems health and human safety

IF 5.3 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Emerging Contaminants Pub Date : 2025-01-01 DOI:10.1016/j.emcon.2024.100460

Chao Zhu , Mingyue Pang , Wenwen Gong , Hengming Pang , Han Qu

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引用次数: 0

Abstract

Increasing numbers of chiral insecticides have been released into aquatic environments, leading to adverse effects on the environment. Furthermore, these insecticides have potentially undesirable side effects on the environment, humans and other non-target species, potentially disrupting entire ecosystems. This study investigated the effects of ethiprole enantiomers against microorganisms in sediment, duckweed, and human cells. The results showed that S-ethiprole degraded preferentially in sediment, demonstrating enantioselective behavior. In sediment, catalase and superoxide dismutase activities were significantly inhibited, and the frond number of duckweed preferably decreased with exposure to S-ethiprole at high concentration treatments (33 : 25 = R-ethiprole: S-ethiprole). Additionally, the content of chlorophyll b decreased nearly 2 times in R-ethiprole (0.42 mg/g) treatment group in comparison to S-ethiprole (0.20 mg/g) treatment. Cytotoxicity test revealed that S-ethiprole was 2 and 3 times more toxic than rac- and R-ethiprole. The expressions of CAT, SOD and caspase-3 were up-regulated in human cells treated with ethiprole enantiomers, indicating oxidative stress as a key factor in toxicity. Overall, S-ethiprole exhibited greater adverse effects than rac- and R-enantiomers in human cells. These findings demonstrate the importance of considering chirality in the risk assessment of harmful chemicals in the aquatic environment.

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来源期刊

Emerging Contaminants Medicine-Public Health, Environmental and Occupational Health

CiteScore

10.00

自引率

6.70%

发文量

审稿时长

44 days

期刊介绍： Emerging Contaminants is an outlet for world-leading research addressing problems associated with environmental contamination caused by emerging contaminants and their solutions. Emerging contaminants are defined as chemicals that are not currently (or have been only recently) regulated and about which there exist concerns regarding their impact on human or ecological health. Examples of emerging contaminants include disinfection by-products, pharmaceutical and personal care products, persistent organic chemicals, and mercury etc. as well as their degradation products. We encourage papers addressing science that facilitates greater understanding of the nature, extent, and impacts of the presence of emerging contaminants in the environment; technology that exploits original principles to reduce and control their environmental presence; as well as the development, implementation and efficacy of national and international policies to protect human health and the environment from emerging contaminants.