A voltammetric sensor based on praseodymium oxide nanoparticles immobilized on tetrahedral boronate esters for favipiravir used in the treatment of COVID-19

IF 5.5 3区工程技术 Q1 ENGINEERING, CHEMICAL

Journal of the Taiwan Institute of Chemical Engineers Pub Date : 2025-01-25 DOI:10.1016/j.jtice.2025.105975

Hilal Incebay , Ahmet Kilic

{"title":"A voltammetric sensor based on praseodymium oxide nanoparticles immobilized on tetrahedral boronate esters for favipiravir used in the treatment of COVID-19","authors":"Hilal Incebay , Ahmet Kilic","doi":"10.1016/j.jtice.2025.105975","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>This research aims to develop a novel electrochemical sensor strategy from the nanocomposite obtained by incorporating praseodymium oxide nanoparticles (Pr<sub><sub>6</sub></sub>O<sub><sub>11</sub></sub>NPs) into tetrahedral boronate esters (BE<sub><sub>1</sub></sub>N) and to use this sensor for the accurate and sensitive detection of Favipiravir drug used in the treatment of COVID-19.</div></div><div><h3>Method</h3><div>BE1N, which our group previously synthesized, and Pr<sub>6</sub>O<sub>11</sub>NPs were subjected to sonication in chloroform to be completely catalyzed, and conductive Pr<sub><sub>6</sub></sub>O<sub><sub>11</sub></sub>NPs/BE<sub><sub>1</sub></sub>N nanocomposite suspension was obtained. Pr<sub><sub>6</sub></sub>O<sub><sub>11</sub></sub>NPs/BE<sub><sub>1</sub></sub>N nanocomposite suspension was immobilized on the surface of the polished glassy carbon electrode (GCE) by the drop drying method, and a working electrode defined as Pr<sub><sub>6</sub></sub>O<sub><sub>11</sub></sub>NPs/BE<sub><sub>1</sub></sub>N/GCE was obtained for electrochemical experiments.</div></div><div><h3>Significant findings</h3><div>Pr<sub><sub>6</sub></sub>O<sub><sub>11</sub></sub>NPs/BE<sub><sub>1</sub></sub>N/GCE was characterized and used to detect Favipiravir using the square wave voltammetry technique. Under optimal conditions, Pr<sub><sub>6</sub></sub>O<sub><sub>11</sub></sub>NPs/BE<sub><sub>1</sub></sub>N/GCE provided an LOD of 0.035 nM in a linear range of 1.0 nM to 20 μM for Favipiravir. Additionally, the nanovoltammetric sensor exhibited highly effective repeatability, reproducibility, and stability while demonstrating negligible performance interference against interfering species. Besides, it was confirmed that the proposed nanovoltammetric sensor could be used for the sensitive detection of Favipiravir in real samples such as pharmaceutical tablets, urine, and human blood serum.</div></div>","PeriodicalId":381,"journal":{"name":"Journal of the Taiwan Institute of Chemical Engineers","volume":"169 ","pages":"Article 105975"},"PeriodicalIF":5.5000,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Taiwan Institute of Chemical Engineers","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1876107025000264","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, CHEMICAL","Score":null,"Total":0}

引用次数: 0

Abstract

Background

This research aims to develop a novel electrochemical sensor strategy from the nanocomposite obtained by incorporating praseodymium oxide nanoparticles (Pr_₆O_₁₁NPs) into tetrahedral boronate esters (BE_₁N) and to use this sensor for the accurate and sensitive detection of Favipiravir drug used in the treatment of COVID-19.

Method

BE1N, which our group previously synthesized, and Pr₆O₁₁NPs were subjected to sonication in chloroform to be completely catalyzed, and conductive Pr_₆O_₁₁NPs/BE_₁N nanocomposite suspension was obtained. Pr_₆O_₁₁NPs/BE_₁N nanocomposite suspension was immobilized on the surface of the polished glassy carbon electrode (GCE) by the drop drying method, and a working electrode defined as Pr_₆O_₁₁NPs/BE_₁N/GCE was obtained for electrochemical experiments.

Significant findings

Pr_₆O_₁₁NPs/BE_₁N/GCE was characterized and used to detect Favipiravir using the square wave voltammetry technique. Under optimal conditions, Pr_₆O_₁₁NPs/BE_₁N/GCE provided an LOD of 0.035 nM in a linear range of 1.0 nM to 20 μM for Favipiravir. Additionally, the nanovoltammetric sensor exhibited highly effective repeatability, reproducibility, and stability while demonstrating negligible performance interference against interfering species. Besides, it was confirmed that the proposed nanovoltammetric sensor could be used for the sensitive detection of Favipiravir in real samples such as pharmaceutical tablets, urine, and human blood serum.

Abstract Image

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of the Taiwan Institute of Chemical Engineers 工程技术-工程：化工

CiteScore

9.10

自引率

14.00%

发文量

362

审稿时长

35 days

期刊介绍： Journal of the Taiwan Institute of Chemical Engineers (formerly known as Journal of the Chinese Institute of Chemical Engineers) publishes original works, from fundamental principles to practical applications, in the broad field of chemical engineering with special focus on three aspects: Chemical and Biomolecular Science and Technology, Energy and Environmental Science and Technology, and Materials Science and Technology. Authors should choose for their manuscript an appropriate aspect section and a few related classifications when submitting to the journal online.