The discovery of high endothelial venules. A historical note

Q3 Medicine

Translational Research in Anatomy Pub Date : 2024-12-03 DOI:10.1016/j.tria.2024.100379

Domenico Ribatti

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引用次数: 0

Abstract

Background

Endothelial cells are a heterogeneous population. There are differences between the different species' endothelium, large and small vessels, and between endothelial cells derived from various microvascular endothelial beds. In this context, endothelial cells of high endothelial venules (HEVs) represent an extremely interesting and not-yet completely investigated cell population.

Methods

A literature search in PubMed on the history of HEVs was conducted. The keywords used in the search criteria were “High endothelial venules,” “Immunity,” “B lymphocytes,” “T lymphocytes,” and “Lymph nodes.” The results were summarized in a short narrative historical review based on published papers on the role of HEVs in immunity, inflammation, and cancer.

Results

HEVs are morphologically characterized by a plump, almost cuboidal appearance, a rounded nucleus, a thicker basement membrane, and a layer of mesenchymal cells outside the basement membrane. HEVs are specialized blood vessels mediating lymphocyte trafficking to lymph nodes and other secondary lymphoid organs. HEVs expand during inflammation in immune-stimulated lymph nodes and are profoundly remodeled in metastatic and tumor-draining lymph nodes.

Conclusion

This article emphasizes the important role of HEVs in immunity, inflammation, and cancer. However, although many aspects of HEVs are still to be discovered, their therapeutic modulation already offers interesting results, especially for cancer treatment.

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高内皮小静脉的发现。历史笔记

内皮细胞是一个异质性的群体。不同种属的内皮细胞、大血管和小血管之间以及不同微血管内皮层衍生的内皮细胞之间存在差异。在这种情况下，高内皮小静脉（HEVs）的内皮细胞代表了一个非常有趣但尚未完全研究的细胞群。方法在PubMed上检索hev病史相关文献。搜索条件中使用的关键词是“高内皮小静脉”、“免疫力”、“B淋巴细胞”、“T淋巴细胞”和“淋巴结”。根据已发表的关于hev在免疫、炎症和癌症中的作用的论文，对这些结果进行了简短的历史回顾。结果细胞形态特征为：细胞核圆，基底膜较厚，基底膜外有一层间充质细胞。hev是专门的血管，介导淋巴细胞运输到淋巴结和其他次要淋巴器官。hev在免疫刺激的淋巴结炎症期间扩大，并在转移性和肿瘤引流淋巴结中被深刻重塑。结论强调hev在免疫、炎症和肿瘤中的重要作用。然而，尽管hev的许多方面仍有待发现，但它们的治疗调节已经提供了有趣的结果，特别是在癌症治疗方面。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Translational Research in Anatomy Medicine-Anatomy

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

25 days

期刊介绍： Translational Research in Anatomy is an international peer-reviewed and open access journal that publishes high-quality original papers. Focusing on translational research, the journal aims to disseminate the knowledge that is gained in the basic science of anatomy and to apply it to the diagnosis and treatment of human pathology in order to improve individual patient well-being. Topics published in Translational Research in Anatomy include anatomy in all of its aspects, especially those that have application to other scientific disciplines including the health sciences: • gross anatomy • neuroanatomy • histology • immunohistochemistry • comparative anatomy • embryology • molecular biology • microscopic anatomy • forensics • imaging/radiology • medical education Priority will be given to studies that clearly articulate their relevance to the broader aspects of anatomy and how they can impact patient care.Strengthening the ties between morphological research and medicine will foster collaboration between anatomists and physicians. Therefore, Translational Research in Anatomy will serve as a platform for communication and understanding between the disciplines of anatomy and medicine and will aid in the dissemination of anatomical research. The journal accepts the following article types: 1. Review articles 2. Original research papers 3. New state-of-the-art methods of research in the field of anatomy including imaging, dissection methods, medical devices and quantitation 4. Education papers (teaching technologies/methods in medical education in anatomy) 5. Commentaries 6. Letters to the Editor 7. Selected conference papers 8. Case Reports